A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian.

The fertile gonad includes cells of two distinct developmental origins: the somatic mesoderm and the germ line. How somatic and germ cells interact to develop and maintain fertility is not well understood. Here, using grafting experiments and transgenic reporter animals, we find that a specific part of the gonad-the germinal zone-acts as a sexual organizer to induce and maintain de novo germ cells and somatic gonads in the cnidarian .

Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.

Developing tissues can self-organize into a variety of patterned structures through the stabilization of stochastic fluctuations in their molecular and cellular properties. While molecular factors and cell dynamics contributing to self-organization have been identified in vivo, events channeling self-organized systems such that they achieve stable pattern outcomes remain unknown. Here, we described natural variation in the fidelity of self-organized arrays formed by feather follicle precursors in bird embryos.

A conserved molecular template underlies color pattern diversity in estrildid finches.

The color patterns that adorn animals' coats not only exhibit extensive diversity linked to various ecological functions but also display recurrences in geometry, orientation, or body location. How processes of pattern formation shape such phenotypic trends remains a mystery. Here, we surveyed plumage color patterns in passerine finches displaying extreme apparent variation and identified a conserved set of color domains.

Trends and variation in vertebrate patterns as outcomes of self-organization.

In extant vertebrates, natural motifs such as coat markings, spongy bone structures, neuronal arborescence or collective swarms correspond to diverse pattern types, from fractals to periodic stripes or tessellations, and so on. In this subphylum, evolution produced an apparent paradox: a given pattern may vary tremendously in its extent, periodicity or regularity, but follows general geometrical trends and is produced with meticulous precision. In this review, we discuss the role of self-organization, a patterning strategy in which spontaneous order arises through local interactions without gradient formation, in shaping both natural pattern differences and common themes.

[The embryonic origin of periodic colour patterns].

Because they vary extensively, the periodic colour motifs that adorn the coat of vertebrates historically served to study the formation and evolution of biological patterns. While two major patterning strategies, namely instructional signalling and self-organisation, have been theorised from numerical and empirical work in model organisms, the origin, nature, and mode of action of factors underlying these strategies in vivo remains unclear. To address this question our laboratory designed a method based on opportunistic surveys of natural variation in periodic plumage motifs.

Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.

The development of an organism involves the formation of patterns from initially homogeneous surfaces in a reproducible manner. Simulations of various theoretical models recapitulate final states of natural patterns, yet drawing testable hypotheses from those often remains difficult. Consequently, little is known about pattern-forming events.

The periodic coloration in birds forms through a prepattern of somite origin.

The periodic stripes and spots that often adorn animals' coats have been largely viewed as self-organizing patterns, forming through dynamics such as Turing's reaction-diffusion within the developing skin. Whether preexisting positional information also contributes to the periodicity and orientation of these patterns has, however, remained unclear. We used natural variation in colored stripes of juvenile galliform birds to show that stripes form in a two-step process.

Neural crest-mediated bone resorption is a determinant of species-specific jaw length.

Precise control of jaw length during development is crucial for proper form and function. Previously we have shown that in birds, neural crest mesenchyme (NCM) confers species-specific size and shape to the beak by regulating molecular and histological programs for the induction and deposition of cartilage and bone. Here we reveal that a hitherto unrecognized but similarly essential mechanism for establishing jaw length is the ability of NCM to mediate bone resorption.