Preoperative predictors of positive margins after loop electrosurgical excisional procedure-Cone.

Objective: A LEEP-Cone may not be necessary for all patients with traditional cone indications. This study defines populations where a single pass technique with the LEEP is appropriate.

Methods: We retrospectively reviewed patients undergoing LEEP-Cone procedures performed at the University of Oklahoma Health Science Center from February of 1994 to July of 2002.

Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma.

The treatment of recurrent ovarian cancer with the combination of gemcitabine and cisplatin chemotherapy has recently been shown to be an active regimen. But the majority of positive responses have been observed in patients considered either platinum-sensitive or who have had extended platinum-free intervals. The purpose of our study was to review our experience with this regimen in women with platinum-resistant ovarian and peritoneal carcinoma with more recent exposure to platinum.

Management of atypical and low-grade cervical cytology.

The finding of atypical and low-grade cervical cytology on routine Papanicolaou test is considered problematic for gynecologists and pathologists. The interpretation and management of these cases can be difficult when Papanicolaou test results fall into the Bethesda 2001 categories of atypical squamous cells, atypical squamous cells--cannot rule out high-grade, atypical glandular cells, or low-grade squamous intraepithelial lesion. Although liquid-based Papanicolaou tests may have resulted in some improvement in detection, a large amount of variability in cytologic interpretations continues to exist.

Uterine papillary serous carcinoma: comparisons of outcomes in surgical Stage I patients with and without adjuvant therapy.

Objective: Our aim was to determine the outcomes of Stage I uterine papillary serous carcinoma (UPSC) patients with and without adjuvant therapy after comprehensive surgical staging.

Methods: Patients with FIGO Stage I UPSC diagnosed from 1987 to 2000 were identified from tumor registry databases at four institutions. A retrospective chart review identified 60 women who underwent comprehensive surgical staging, including a total hysterectomy, bilateral salpingo-oophorectomy, pelvic/para-aortic lymphadenectomy, and peritoneal cytology.