Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis.

Context: Mechanisms explaining exercise-induced β-cell health are unknown.

Objective: This study aimed to define the role of muscle contraction and acute exercise-derived soluble humoral mediators on β-cell health.

Design: In vitro models were used.

The acute effects of interval- Vs continuous-walking exercise on glycemic control in subjects with type 2 diabetes: a crossover, controlled study.

Context: Glycemic control improves with physical activity, but the optimal exercise mode is unknown.

Objective: The objective of the study was to determine whether interval-based exercise improves postprandial glucose tolerance and free-living glycemia more than oxygen consumption- and time duration-matched continuous exercise.

Design: This was a crossover, controlled study with trials performed in randomized order.