Publications by authors named "Camilla R V Blain"
Objective: Depression is a common, serious, but under-recognised problem in multiple sclerosis (MS). The primary objective of this study was to assess whether a rapid visual analogue screening tool for depression could operate as a quick and reliable screening method for depression, in patients with MS.
Method: Patients attending a regional MS outpatient clinic completed the Emotional Thermometer 7 tool (ET7), the Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D) and the Major Depression Inventory (MDI) to establish a Diagnostic and Statistical Manual, 4th edition (DSM-IV) diagnosis of Major Depression.
Article Synopsis
- Progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and idiopathic Parkinson's disease (IPD) often present similarly in early stages, making diagnosis challenging despite having different underlying causes.
- Advanced structural neuroimaging techniques, specifically multi-class pattern recognition, were used to differentiate these conditions from each other and from healthy controls by analyzing specific brain regions, particularly the midbrain/brainstem.
- The findings indicate that structural MRI can effectively assist in diagnosing individual patients with these Parkinsonian disorders by identifying unique patterns of brain atrophy associated with each condition.
Background: The basis of heterogeneity in the clinical presentation and rate of progression of amyotrophic lateral sclerosis (ALS) is poorly understood.
Objectives: To use diffusion tensor imaging as a measure of axonal pathologic features in vivo in ALS and to compare a homogeneous form of familial ALS (homozygous D90A SOD1 [superoxide dismutase 1]) with sporadic ALS.
Design: Cross-sectional diffusion tensor imaging study.
In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes in diffusion variables reflected clinical deterioration. Twenty-three ALS patients and 25 healthy volunteers underwent whole brain DTI. Patients and a subset (n = 12) of controls returned for a second scan.
View Article and Find Full Text PDFThe neural correlates of motor execution in Amyotrophic Lateral Sclerosis (ALS) are challenging to investigate due to muscle weakness. Alternatives to traditional motor execution paradigms are therefore of great interest. This study tested the hypothesis that patients with Amyotrophic Lateral Sclerosis (ALS) would show increased cortical activation during motor imagery compared to healthy controls, as seen in studies of motor execution.
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