Does parametric fMRI analysis with SPM yield valid results? An empirical study of 1484 rest datasets.

The validity of parametric functional magnetic resonance imaging (fMRI) analysis has only been reported for simulated data. Recent advances in computer science and data sharing make it possible to analyze large amounts of real fMRI data. In this study, 1484 rest datasets have been analyzed in SPM8, to estimate true familywise error rates.