Myricitrin from Exhibits Inhibitory Effect on DNA-Topoisomerase Type II and Protective Effect Against Doxorubicin-Induced Mutagenicity.

Flavonoids-compounds abundant in balanced daily diets-have been extensively investigated for biological activity. The pronounced antiproliferative effects of flavonoids have prompted studies to elucidate their mode of action against tumor cells. The anticancer properties of myricetin, a 3',4',5'-tri-hydroxylated flavonol, have been confirmed for a number of neoplasms, but myricitrin, its 3--rhamnoside derivative found in fruits and other parts of edible plants, has been scarcely investigated as a chemopreventive agent.