Characterization of and Plasmids of a ST11 Outbreak Clone.

The most common resistance mechanism to carbapenems is the production of carbapenemases. In 2021, the Pan American Health Organization warned of the emergence and increase in new carbapenemase combinations in in Latin America. In this study, we characterized four isolates harboring and from an outbreak during the COVID-19 pandemic in a Brazilian hospital.

Polymyxin Resistance Among XDR ST1 Carbapenem-Resistant Clone Expanding in a Teaching Hospital.

is an opportunistic pathogen primarily associated with multidrug-resistant nosocomial infections, for which polymyxins are the last-resort antibiotics. This study investigated carbapenem-resistant strains exhibiting an extensively drug-resistant (XDR) phenotype, including four isolates considered locally pan drug-resistant (PDR), isolated from inpatients during an outbreak at a teaching hospital in Brazil. ApaI DNA macrorestriction followed by PFGE clustered the strains in three pulsotypes, named A to C, among carbapenem-resistant strains.

Dissemination of bla in an NTE by an IncX5 plasmid.

bla is disseminated worldwide usually in Tn4401, a Tn3-family transposon, and primarily in Klebsiella pneumoniae ST258, a well-known lineage that is distributed worldwide and responsible for several outbreaks. Although occurring rarely, bla has been described in non-Tn4401 elements (NTE), first in China and then in a few other countries. This study reports the dissemination of a bla-carrying NTE among ST11/CG258 K.