CD160 Stimulates CD8 T Cell Responses and Is Required for Optimal Protective Immunity to .

CD160 promotes NK cell cytotoxicity and IFN-γ production, but the function of CD160 on CD8 T cells remains unclear with some studies supporting a coinhibitory role and others a costimulatory role. In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8 T cell effector functions needed for optimal clearance of oral infection. CD160 mice did not clear oral as efficiently as wild type (WT) littermates.