Publications by authors named "Camila Goncalves Dos Santos"
Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through , , and approaches.
Débora Leite Campos Christian Shleider Carnero Canales Fernanda Manaia Demarqui Guilherme F S Fernandes Camila Gonçalves Dos Santos Jean Leandro Dos Santos
Front Microbiol
October 2024
Article Synopsis
- - Tuberculosis (TB) is a major global health issue, worsened by drug-resistant strains, and this study examines two benzofuroxan derivatives, 5n and 5b, as new treatment options for multi-drug resistant TB (MDR-TB).
- - Compound 5n showed impressive antibacterial activity against the H37Rv strain, with a minimum inhibitory concentration (MIC) of 0.09 μM, and it performed better against MDR and pre-XDR strains compared to standard TB drugs, while being less harmful to gut microbiota.
- - The research indicates that 5n could be combined with rifampicin to boost treatment effects, and it effectively reduces bacterial load in the lungs more