Publications by authors named "Camila Freze Baez"
The increased risk for opportunistic infections after a renal transplant requires monitoring of viral infections to avoid future complications. Our goal was to investigate the impact and factors associated with Epstein-Barr virus (EBV), human cytomegalovirus (HCMV) and human herpesvirus type 6 (HHV-6) viremia in renal transplant recipients. Whole blood samples were collected monthly from 82 patients during the first semester and then quarterly up to 1 year after transplantation.
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- This study explores the connection between non-melanoma skin cancers (NMSC) and certain viruses: Merkel cell polyomavirus (MCPyV), Epstein-Barr virus (EBV), and human papillomavirus (HPV).
- The researchers found that 75% of NMSC samples tested positive for at least one virus, with HPV being particularly frequent (43%) in NMSC compared to only 6.7% in non-cancerous samples.
- The findings suggest a potential link between HPV and NMSC, as well as associations between MCPyV and UV exposure and EBV with immune system compromise, indicating a need for further research on the role of these viruses in skin cancer development.
Article Synopsis
- About 40 years ago, researchers identified and studied two key proteins (large T-antigen and small T-antigen) of the simian vacuolating virus 40, a type of polyomavirus.
- These proteins are found in all known human polyomaviruses and are crucial for early viral replication and tumor development.
- The review highlights the structural and functional characteristics of these proteins, emphasizing their role in transforming cells and contributing to the development of certain tumors in humans.
Simultaneous Porcine circovirus type 2 (PCV-2) and Torque teno sus virus (TTSuV) infections have been reported around the world, generally linked to severe infections. In the present study, 257 swine plasma samples from 31 swine herds located in Brazil, were PCR screened for PCV-2 and TTSuV-1/2 and correlated with clinical data. PCV-2 was detected in 25%, followed by 38.
View Article and Find Full Text PDFThe aim of this study was to investigate the association of EBV and HPV with gingivitis and/or periodontitis according to the immunologic status. To this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by PCR for both viruses. According to the results, EBV was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.
View Article and Find Full Text PDFMerkel cell polyomavirus (MCPyV) large T antigen (LT-ag) is frequently found truncated in Merkel cell carcinomas (MCC) and it is considered a major tumor-specific signature. Nonetheless, the biological role of LT-ag nontruncated mutations is largely unknown. In this study, MCPyV LT-ag second exon from 11 non-MCC oral samples and NCBI sequences derived from different anatomical sites were studied from the genetic and structural standpoint.
View Article and Find Full Text PDFMerkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cancer, with approximately 80% of cases associated with Merkel cell polyomavirus (MCPyV). The lack of information concerning its occurrence in non-MCC immunosuppressed populations led to the investigation of MCPyV DNA in saliva and oral biopsies from 60 kidney allograft recipients and 75 non-transplanted individuals (control group). In contrast to herpesviruses, which was also investigated (CMV, HHV-6A, and B, HHV-7) MCPyV was detected predominantly in patients with oral lesions (gingivitis and/or periodontitis) of both transplanted and non-transplanted groups (P=0.
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