In situ protocol for the determination of dose-response effect of low-fluoride dentifrices on enamel remineralization.

Unlabelled: No in situ protocol has assessed the dose-response effects of fluoride dentifrices involving low-fluoride formulations.

Objective: To assess the ability of an in situ remineralization model in determining dose-response effects of dentifrices containing low fluoride concentrations ([F]) on bovine enamel.

Material And Methods: Volunteers wore palatal appliances containing demineralized enamel blocks and brushed their teeth and devices with the dentifrices supplied (double-blind, crossover protocol) separately for 3 and 7 days.