Publications by authors named "Camila Favero de Oliveira"
The aim of the present study was to evaluate the cytotoxicity of root canal sealers under conditions closely resembling a clinical reality. A primary human fibroblast cell line was seeded in 24-well acrylic plates with Dulbecco's modified Eagle's medium supplemented with 10% serum fetal bovine (SFB) and incubated for 24 h. Root canals from premolars were filled and individually attached to nylon devices to be stabilized in the wells with the already seeded cells.
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- Eugenol (EUG), a compound found in cloves, shows anti-cancer properties by affecting various mechanisms in cancer cells, including breast, melanoma, and colon cancers.
- The study hypothesizes that EUG causes an increase in reactive oxygen species (ROS), leading to cell cycle disruptions, mitochondrial toxicity, and ultimately cell death in melanoma and cervical cancer cells.
- Results demonstrated that EUG indeed raises ROS levels, disrupts the cell cycle, downregulates key proteins, and triggers apoptosis, indicating its potential as a supportive treatment in cancer therapy.
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- This study investigates the cytotoxic effects of zoledronic acid (ZA), a bisphosphonate drug, on human epithelial cells and gingival fibroblasts to understand its link to bisphosphonate-induced osteonecrosis.
- The researchers cultured cells, exposing them to a 5 µM concentration of ZA for 48 hours, and assessed various parameters including cell viability and morphology.
- Results showed that ZA significantly reduced viable cell counts and metabolic activity in both cell types, with notable changes in cell structure, suggesting a potential mechanism for the drug's role in osteonecrosis development.
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- The study analyzed the effects of a resin-modified glass-ionomer cement (RMGIC) on dentin with various thicknesses of smear layer regarding transdentinal cytotoxicity (TC) and bond strength (BS).
- Forty dentin discs with thick (TSL) and thin (THSL) smear layers underwent treatments to assess cell viability and bond strength, with significant results showing decreased cell metabolism in treated groups compared to control.
- Overall, while RMGIC exhibited moderate cytotoxic effects on MDPC-23 cells, the presence or removal of the smear layer did not significantly change its bond strength to dentin.
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- The study aimed to assess the cytotoxic effects of the self-etch resin-based luting cement, RelyXUnicem, under different curing conditions, with or without the placement of ceramic discs.
- Researchers created seven groups of specimens to evaluate the impact on cultured odontoblast-like cells, measuring indicators like cell metabolism, total protein dosage, and alkaline phosphatase activity after exposure to cement extracts.
- Results indicated that the chemical curing process without ceramic interposition led to mild cytotoxic effects, while dual curing without ceramic showed no cytotoxicity; significant cell metabolism and protein reductions were noted with certain groups.
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- This study investigates how dentin permeability affects the transmission of LED light (630 nm) through dentin, with potential implications for clinical phototherapy to enhance pulp healing.
- A series of experiments were conducted using 45 dentin disks from human molars, measuring light transmission before and after treating the disks to remove the smear layer.
- Results showed a weak correlation (coefficient = 0.19) between dentin permeability and light attenuation, indicating that the level of permeability does not significantly impact light propagation, while treating with EDTA improved light transmission significantly.