Publications by authors named "Camila Costa Souza"
Clin Nephrol Case Stud
January 2024
Article Synopsis
- Drug-induced hypomagnesemia can have serious and potentially fatal consequences, particularly from long-term use of proton pump inhibitors (PPIs), which impair magnesium absorption in the intestines.
- The mechanisms involve reduced transport of magnesium through specific cellular channels (TRPM6 and TRPM7) and a decrease in paracellular absorption due to downregulated claudins.
- Two cases are highlighted where PPI use led to electrolyte disorders resulting in cardiac arrhythmia, cognitive changes, and seizures, emphasizing the importance of monitoring magnesium levels in high-risk patients.
