Publications by Camila Bastos Tavares Teixeira

Publications by authors named "Camila Bastos Tavares Teixeira"

Braz J Microbiol

December 2024

Enterobacter cloacae complex is a significant multidrug-resistant pathogen found in hospitals, prompting a study on its antimicrobial resistance and genetic factors in Brazil.
The study screened 94 clinical isolates, finding 20.2% (19 isolates) resistant to colistin, with high levels of resistance indicated by MIC values ranging from 4 to 128 µg/mL.
Genetic analysis revealed several carbapenemase and polymyxin resistance genes, along with diverse genetic profiles among the isolates, but no predominant clone was established.

Braz J Microbiol

March 2023

Carbapenems are crucial last-resort antibiotics for treating infections from multidrug-resistant Gram-negative bacteria, but resistance through mechanisms like OprD loss and carbapenemases is a growing global concern.
A study in Brazil tested the effectiveness of three phenotypic tests—Carba NP, Blue Carba, and mCIM/eCIM—to detect carbapenemase-producing Pseudomonas species, using 127 clinical isolates.
Results showed that Carba NP had the highest sensitivity and successfully differentiated between carbapenemases types, while Blue Carba struggled with class B detection, highlighting the need for improved and more reliable resistance detection methods.

Front Cell Infect Microbiol

August 2022

- The study assessed 502 Enterobacteriales isolates in Brazil for resistance to polymyxins, specifically colistin, revealing a 29.5% resistance rate and confirming all isolates as multidrug-resistant (MDR).
- Genetic analysis indicated that 77% of isolates harbored carbapenemase genes, with various molecular typing methods identifying significant diversity, including 51 pulsotypes and 21 sequence types (STs), notably ST437, ST258, and ST11.
- The research identified key chromosomal mutations and insertion sequences linked to increased resistance, highlighting the emergence of high-risk clones such as CC11 in Brazil, raising concerns about global implications for antibiotic resistance.

Infect Genet Evol

August 2022

High rates of carbapenem resistance in Brazilian Pseudomonas aeruginosa are linked to a specific clone (ST277) that produces a type of carbapenemase called SPM-1.
Researchers used whole genome sequencing to analyze the genetic make-up of a plasmid containing the bla gene in these resistant isolates and found a new bla-plasmid.
The study highlights the urgent need for public health measures to track the spread of this plasmid due to its connection with a high-risk bacterial clone.

Front Med (Lausanne)

March 2021

Multidrug-resistant gram-negative bacilli (GNB) are a significant global health issue, especially when linked to bloodstream infections (BSI), which worsen patient outcomes.
Whole-genome sequencing was used to study these pathogens in Brazil, revealing high-risk clones like CC258, ST79, and ST233, along with their resistance mechanisms.
Key findings included associations between specific gene variants and clones, the identification of new MDR clone ST3079, and a novel clonal profile ST848, which could inform future strategies for managing BSI and other hospital-acquired infections.

Microb Drug Resist

May 2021

- Emergence of colistin-resistant bacteria with mobile resistance genes is a growing threat to both animals and humans involved in food production.
- The article focuses on identifying a specific plasmid that carries colistin resistance genes in poultry, highlighting its role as a new reservoir for these genes.
- Three closely related bacterial strains were isolated from cloacal swabs, and their genomes included a significant plasmid that potentially facilitates the spread of colistin resistance.