Background: Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease worldwide, with significant morbidity associated with nonalcoholic steatohepatitis (NASH). Genome-wide association studies demonstrated that the variants rs738409 C/G in the and rs58542926 C/T in the genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD progression.
Aim: To investigate and genotype frequency and their association with NAFLD development and progression in Brazilian patients.