25-Year Experience with Replacement of the Human Bladder (Camey Procedure).

The Carney enterocystoplasty is a technique for constructing a functional, continent bladder in male patients following cystoprostatectomy for carcinoma. The technique is described and 84 patients treated during a 25-year interval are reviewed.

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.

Objective: ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).

Methods: The best candidates from fine-mapping analysis of 21 ABCB1 SNPs tagging C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642) were analysed in 4616 European invasive EOC patients from thirteen Ovarian Cancer Association Consortium (OCAC) studies and The Cancer Genome Atlas (TCGA).

Update on the Camey II procedure.

Between January 1987 and January 1991, 110 detubularized U-shaped ileocystoplasties (Camey II) following radical cystectomy were carried out in our Department of Urology (CMC Foch Suresnes, France). Our first evaluation of this procedure was carried out in 1989 and reviewed initial 57 patients operated on. These data were compared with those of the Camey I operation.

[T1 G3 bladder tumors: the respective role of BCG and cystectomy].

Forty eight patients with T1 G3 bladder cancer were treated between 1975 and 1991. An associated carcinoma in situ in one third of cases. Twenty six patients received intravesical BCG instillations (an average of 2.

[The future of total substitution ileoplasty].

Up to now radical cystectomy with or without ancillary methods (radiotherapy, chemotherapy) has been usually considered as the most efficient treatment for invasive bladder cancer. Bladder replacement, which maintains body image, made this mutilation more acceptable for the patient and more easily offered for early stages T1b, T2. According to the progresses of oncologic knowledge, chemotherapy, immunotherapy, it seems reasonable to think that within less than 10 years, conservative treatments for bladder cancer will probably make obsolete radical cystectomy and, of course, associated bladder replacement.

[Fibrous polyps of the urinary tract].

The authors report five cases of fibrous polyps of the urinary tract, which is a rare disease, as Mazeman only reported 12 cases in his review in 1972. These cases confirm the polymorphic nature of the clinical presentation and the site of these tumours of mesodermal origin, essentially composed of richly vascular connective tissue covered with surface epithelium. Treatment is surgical and conservative.

[Inhibition of bacterial adherence by nitroxoline on cellular adhesion and on urinary catheter surfaces].

Nitroxolin or 5-nitro-8-hydroxyquinoline, used in the treatment of acute or recurrent uncomplicated urinary tract infection (UTI), has been investigated to demonstrate inhibitory effect on bacterial adherence to epithelial cells or solid surfaces. Nitroxolin in vitro and in urine inhibits bacterial adherence of E. coli 38 (MS/MS) on HeLa cells and epithelial cells from human bladder mucosa.

Complications of the Camey procedure.

Since the authors' first case in 1958, 221 bladder replacements in more than 500 radical cystectomies have been performed in their department. They discuss perioperative complications; postoperative complications including mortality, gastrointestinal problems, urologic problems, and infections; and late complications such as ileal bladder problems, upper urinary tract problems, secondary diversions, and incontinence.

An original antireflux ureteroileal implantation technique: long-term followup.

An original ureteroileal reimplantation technique in which the ureter is placed in a sulcus created in the ileal mucosa was performed on 51 patients (97 ureters). Followup ranged from 3 to 8 years. As determined by excretory urography, retrograde ileography and urine bacteriology studies the method was effective in 85 per cent of the patients, with a low rate of stenosis (1.

Esophageal cancer metastatic to kidney: report of 2 cases.

We report 2 cases of renal tumor secondary to an esophageal cancer and discovered during an examination for hematuria. Despite the history the existence of a renal tumor with no apparent metastatic spread and hematuria justified nephrectomy, which led to the confirmation of metastasis to the kidney. Metastases of esophageal cancers represent only 4.

[Antireflux uretero-ileal implantation via a mucosal sulcus].

The authors present an original antireflux uretero-ileal implantation. This procedure is based on the insertion of the ureter in a mucosal sulcus. The ileal mucosa progressively grows over the ureter.