Purpose: To evaluate the effectiveness of sequential custom phototherapeutic keratectomy (SCTK) for granular corneal dystrophy type 1 (GCD1).
Methods: Thirty-seven eyes of 21 patients with GCD1 were treated with SCTK to remove superficial opacifications, regularize the corneal surface, and decrease optical aberrations. SCTK is a sequence of custom therapeutic excimer laser keratectomies with step-by-step intraoperative corneal topography monitoring of results.
Purpose: To investigate if symptomatic conjunctivitis during the recovery phase of the disease could be associated to a persistent presence of SARS-CoV-2 in the upper respiratory tract. Secondary end points were to analyze the presence of SARS-CoV-2 in the conjunctiva of ocular symptomatic patients and to record the presence of ocular disturbances at this point of the disease.
Methods: An observational study including consecutive COVID19 patients treated at Humanitas Clinical and Research Hospital who were attending for nasopharyngeal swab to confirm the resolution of SARS-CoV-2 infection and end of isolation.
Purpose: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted for patients with elective problems.
View Article and Find Full Text PDFPurpose: To report long-term outcomes of sequential customized therapeutic keratectomy for Reis-Bücklers' corneal dystrophy.
Methods: This was a retrospective review of 14 eyes of 8 patients with Reis-Bücklers' corneal dystrophy that underwent surgical peeling with a spatula of the epithelium and subepithelial membrane present in Reis-Bücklers' corneal dystrophy, with subsequent sequential customized therapeutic keratectomy featuring a multi-step approach with sequential, repeated customized excimer laser photoablations alternating with repeat intraoperative topographies to monitor and progressively reduce corneal irregularities.
Results: At the last follow-up of 5.
Purpose: To evaluate long-term results of sequential customized therapeutic keratectomy (SCTK) in highly aberrated corneas with apical scars consequent to hyperopic excimer laser refractive surgery.
Methods: Fifteen eyes of 12 patients treated with SCTK for a corneal apical scar after hyperopic excimer laser refractive surgery were retrospectively evaluated. SCTK is a sequence of custom therapeutic excimer laser keratectomies where the results are monitored step-by-step by intraoperative corneal topography.
Purpose: To compare the clinical performance and safety of 2 ophthalmic viscosurgical devices (OVDs)-Twinvisc (OVD 1) and Duovisc (OVD 2)-in cataract surgery.
Setting: European multicenter study.
Design: Prospective randomized controlled study.
Purpose: To compare visual outcomes and postoperative aberrations after surface ablation performed with a 750-Hz versus a 1,050-Hz excimer laser coupled with an ablation software designed to reduce corneal surface irregularity.
Methods: Retrospective comparative trial of myopic eyes that had refractive surgery consecutively treated with transepithelial advanced surface ablation with a 750-Hz excimer laser (750 group) versus a 1,050-Hz excimer laser coupled with the Smart Pulse Technology ablation software (SPT group). The SPT algorithm is a laser pulse technology software aimed at reducing surface irregularity of the stromal bed at the end of treatment.
Background: Change in lesion volume over time, measured on brain magnetic resonance imaging (MRI) scans, is an important outcome measure for natural history studies and clinical trials in multiple sclerosis (MS).
Purpose: To develop and test image analysis methods for quantification of lesion volume change in order to improve reliability.
Methods: The technique is based on registration and subtraction, and was evaluated in a cohort of 20 MS patients with dual-echo images acquired annually over a period of four years.
Purpose: To report initial clinical results of transepithelial corneal collagen cross-linking with iontophoresis (I-CXL).
Methods: Twenty eyes of 20 patients diagnosed as having progressive keratoconus who underwent I-CXL were included in this prospective non-randomized clinical study. Corrected distance visual acuity (CDVA), spherical equivalent and cylinder refraction, various corneal topography and Scheimpflug tomography parameters, aberrometry, anterior segment optical coherence tomography, and endothelial cell count were assessed at baseline and at 1, 3, 6, and 12 months postoperatively.
Purpose: To compare biomechanical effect, riboflavin penetration and distribution in transepithelial corneal collagen cross-linking with iontophoresis (I-CXL), with standard cross linking (S-CXL) and current transepithelial protocol (TE-CXL).
Materials And Methods: The study was divided into two different sections, considering, respectively, rabbit and human cadaver corneas. In both sections corneas were divided according to imbibition protocols and irradiation power.
Purpose: To report the 4-year outcomes of corneal cross-linking (CXL) for progressive keratoconus in a population of different age groups.
Design: Retrospective, single-center, nonrandomized clinical study.
Participants: Four hundred consecutive eyes treated with corneal CXL for progressive keratoconus from April 2006 through April 2010.
Purpose: To determine the incidence of vitreopapillary adhesion (VPA) and to investigate its value as a prognostic factor in the surgical outcome of pseudo- (PMH) and lamellar macular holes (LMH).
Methods: A total of 76 consecutive patients, diagnosed with PMH (41 eyes) or LMH (35 eyes) were included. Eyes with VPA were alternatively assigned to the surgical or control group.
Purpose: To report a case of bilateral, ring-shaped, intrastromal corneal opacities after corneal cross-linking (CXL) for progressive keratoconus.
Methods: A 21-year-old man with bilateral, progressive keratoconus underwent CXL with riboflavin 0.1% and ultraviolet A (UVA) light in the right eye and, 6 months later, in the left eye.
Objective: To compare interferon β-1b (IFNβ-1b) and glatiramer acetate (GA) on new lesion (NL) (gadolinium-enhancing, new T2) evolution into permanent black holes (PBH)--a marker of irreversible tissue damage--in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods: BEYOND was a large, phase III, clinical trial comparing IFNβ-1b 250 μg, IFNβ-1b 500 μg, and GA (2:2:1). Patient scans were reexamined post hoc for PBH in a rater-blinded manner.
Purpose: To evaluate the 1-year results of corneal collagen cross-linking (CXL) in eyes with postoperative excimer laser refractive surgery corneal ectasia.
Methods: Thirteen eyes of 9 consecutive patients who had undergone excimer laser refractive surgery (photorefractive keratectomy [n = 3], LASIK [n = 10]) with resultant unstable corneal ectasia underwent CXL with photosensitizing riboflavin 0.1% solution and subsequent exposure to ultraviolet radiation.
Purpose: To report the outcomes of topography-guided photorefractive keratectomy (PRK) for the treatment of myopia with or without astigmatism using the customized aspheric transition zone (CATz) ablation algorithm.
Methods: In this study, 335 eyes underwent PRK using the NIDEK Advanced Vision Excimer laser platform (NAVEX). Mean preoperative manifest refraction spherical equivalent was -4.
Purpose: To compare the long-term refractive outcomes and changes in higher order wavefront aberrations in patients undergoing photorefractive keratectomy (PRK) with topography-guided (CATz) or wavefront-guided (OPDCAT) ablation algorithm using the NIDEK Advanced Vision Excimer Laser System (NAVEX).
Methods: A retrospective 12-month follow-up study was conducted of 226 eyes undergoing PRK. The NIDEK EC-5000 CX II excimer laser and Final Fit 1.
Purpose: To compare two different postcataract surgery antibiotic/steroid therapeutic combinations, for clinical results as well as patient satisfaction.
Methods: Prospective randomized clinical trial of patients with bilateral operative cataract. Postoperatively, for 15 days one eye was randomly assigned to therapy with the combination chloramphenicol 0.
Purpose: To evaluate visual acuity and long-term stability after phototherapeutic keratectomy (PTK) in patients with corneal thickness less than 400 microm and cornea-related vision problems.
Setting: Department of Ophthalmology, Istituto Clinico Humanitas, Rozzano-Milan, Italy.
Methods: This retrospective study comprised 48 eyes that had PTK for complications after photorefractive keratectomy that removed more than 200 microm of tissue.
J Cataract Refract Surg
January 2005
Purpose: To evaluate the results of custom laser-assisted subepithelial keratectomy (LASEK) with a specially designed transition zone and smoothing for the treatment of refractive errors.
Setting: Department of Ophthalmology, Istituto Clinico Humanitas, Rozzano-Milan, Italy.
Methods: This prospective study involved myopic eyes having refractive surgery with the butterfly LASEK technique and the Nidek EC-5000 excimer laser.
Purpose: Treatment of highly aberrated eyes with opacities or irregularities consequent to previous refractive treatment, ulcers, keratitis, trauma, or corneal dystrophies remains a challenge for refractive surgeons. We evaluated the results of custom phototherapeutic keratectomy (CPK) with intraoperative corneal topography-based aberrometry and custom ablation in highly aberrated eyes.
Methods: We prospectively evaluated eyes undergoing custom phototherapeutic keratectomy (CPK) with custom ablation for corneal opacities and/or irregularities due to previous refractive treatment, keratitis, trauma, or dystrophies.
Purpose: Phototherapeutic keratectomy is a safe and effective treatment for many superficial diseases of the cornea. We applied intraoperative, epithelium-free, topography-based corneal aberrometry as a basis for custom phototherapeutic keratectomy (CPK) in highly aberrated eyes with opacities or irregularities consequent to previous refractive treatment, ulcers, keratitis, trauma or corneal dystrophies.
Methods: We evaluated eyes undergoing CPK for corneal opacities and or irregularities due to previous refractive treatment, keratitis, trauma, or corneal dystrophies, and treated 52 eyes of 50 patients.
Purpose: To evaluate long-term results of custom laser epithelial keratomileusis (LASEK) for correction of myopia and hyperopia using the Custom Ablation Transition Zone (CATz) software and hyaluronic acid masking fluid (Laservis) for final corneal smoothing.
Methods: We conducted a prospective study of 297 eyes of 167 patients. All eyes had LASEK for correction of myopia or hyperopia.
Purpose: To determine corneal aberrometric values in a normal population.
Methods: Corneal topography from a group of 4340 patients was retrospectively evaluated. Exclusion criteria were applied in order to select a population with good visual acuity, no previous ocular surgery, no contact lens influence, and no corneal disease.