Publications by authors named "Cameron Wick"
Objective: To investigate management practices and outcomes in a retrospective cohort of patients who have sustained temporal bone gunshot wounds (TBGSW).
Study Design: Retrospective chart review.
Setting: Five participating hospitals.
Objective: To validate electrocochleography (ECochG) between an auditory evoked potential (AEP) machine and an established cochlear implant (CI) manufacturer ECochG system.
Methods: Intraoperative validation study at a tertiary referral center. Patients included adults and children undergoing cochlear implantation.
Objective: To describe the collection methods for perilymph fluid biopsy during cochlear implantation, detect levels of amyloid β 42 and 40 (Aβ and Aβ), and total tau (tTau) analytes with a high-precision assay, to compare these levels with patient age and Montreal Cognitive Assessment (MoCA) scores, and explore potential mechanisms and relationships with otic pathology.
Study Design: Prospective study.
Setting: Tertiary referral center.
Purpose: This study aims to characterize patterns in ototoxicity monitoring and identify potential barriers to audiologic follow-up.
Methods: We performed a single-institution retrospective cohort study on adult (≥ 18 years old) cancer patients treated with cisplatin from January 2014 to September 2021. Our primary outcomes were rates of baseline and post-treatment audiograms at the following time points: 3, 6, 12, and greater than 12 months.
Objective: To examine the association between preoperative comorbidities and cochlear implant speech outcomes.
Study Design: Retrospective cohort.
Setting: Tertiary referral center.
Article Synopsis
- Vestibular schwannomas (VS) are non-cancerous tumors that can cause significant health issues, but how their diversity and surrounding environment affect their development is not well understood.
- The study utilized single-cell RNA sequencing (scRNA-seq) and other genomic techniques on various VS samples, discovering different types of cells involved in the tumor environment and revealing a link between certain Schwann cells and inflammation often seen in nerve injuries.
- Findings suggest that these Injury-like Schwann cells may promote tumor growth by attracting immune cells through a specific signaling pathway, highlighting potential targets for future therapies.
Objective: To evaluate the predictive value of intracochlear electrocochleography (ECochG) for identifying tip fold-over during cochlear implantation (CI) using the slim modiolar electrode (SME) array.
Study Design: Prospective cohort study.
Setting: Tertiary referral center.
Objective: To evaluate the impact of preoperative and perioperative factors on postlinguistic adult cochlear implant (CI) performance and design a multivariate prediction model.
Study Design: Prospective cohort study.
Setting: Tertiary referral center.
Objectives: Evaluate factors associated with adherence to ototoxicity monitoring among patients with head and neck cancer treated with cisplatin and radiation therapy at a tertiary care center.
Methods: We performed a single-institution retrospective cohort study on adults with head and neck cancer treated with cisplatin and radiation therapy who participated in an ototoxicity monitoring program. The primary outcomes were rates of post-treatment audiograms at the following time points: one, three, six, 12, and greater than 12 months.
Intraoperative Cochlear Nerve Monitoring in Vestibular Schwannoma Microsurgery.
Otolaryngol Clin North Am
June 2023
Monitoring the cochlear nerve during vestibular schwannoma (VS) microsurgery depends on the hearing status and surgical approach. Traditional hearing preservation VS microsurgery relies on acoustically driven auditory brainstem response (ABR) and cochlear nerve action potential. Both modalities have advantages and disadvantages that need to be understood for proper implementation.
View Article and Find Full Text PDFObjective: To explore whether deintensification of adjuvant therapy reduces ototoxicity among patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).
Study Design: Retrospective cohort study.
Setting: Single academic center.
One-Year Hearing Preservation and Speech Outcomes Comparing Slim Modiolar and Lateral Wall Arrays.
Otolaryngol Head Neck Surg
August 2023
Objective: Compare postoperative speech outcomes in hearing preservation (HP) cochlear implantation (CI) patients with a low-frequency pure-tone average (LFPTA) ≤ 60 dB using 2 electrode array designs.
Study Design: Retrospective cohort study.
Setting: Large academic cochlear implant referral center.
Objective: Comprehensively analyze tumor control and treatment complications for jugular paraganglioma patients undergoing surgery versus stereotactic radiosurgery (SRS).
Databases Reviewed: EMBASE, Medline, and Scopus.
Methods: The databases were searched for English and Spanish articles from January 1, 1995, to January, 1, 2019, for studies reporting tumor control and treatment side effects regarding patients with jugular paraganglioma treated with surgery or SRS.
Objective: This study aimed 1) to measure the effect of cochlear implantation on health-related quality of life (HR-QOL) using the Cochlear Implant Quality of Life (CIQOL) questionnaire and 2) to determine audiologic, demographic, and non-CI/hearing-related QOL factors influencing the CIQOL.
Study Design: Prospective observational study.
Setting: Tertiary referral center.
Objectives: To examine long-term speech and cognition outcomes in older adult cochlear implant (CI) recipients. First, by evaluating if CI performance was maintained over an extended follow-up period regardless of preoperative cognitive status. Secondly, by evaluating if there was a difference in the rate of cognitive decline between preoperative mild and normal cognition following CI over an extended period of time.
View Article and Find Full Text PDFObjective: To assess the clinical application of five recently published cochlear implant (CI) candidacy evaluation (CICE) referral screening tools through external validation.
Study Design: Retrospective cohort study.
Setting: Tertiary otology/neurotology practice.
Comparison of endoscopic underlay and over-under tympanoplasty techniques for type I tympanoplasty.
Laryngoscope Investig Otolaryngol
August 2022
Objective: To compare the indications and efficacy of endoscopic over-under tympanoplasty versus endoscopic underlay tympanoplasty.
Methods: Retrospective cohort study of patients undergoing type I endoscopic tympanoplasty via either an underlay or over-under technique by a single surgeon from 2017 to 2021. Patients were excluded if they had a concurrent mastoidectomy, ossiculoplasty, or advanced cholesteatoma defined by involvement of multiple subsites.
Objectives: Electrocochleography (ECochG) recordings during cochlear implantation have shown promise in estimating the impact on residual hearing. The purpose of the study was (1) to determine whether a 250-Hz stimulus is superior to 500-Hz in detecting residual hearing decrement and if so; (2) to evaluate whether crossing the 500-Hz tonotopic, characteristic frequency (CF) place partly explains the problems experienced using 500-Hz.
Design: Multifrequency ECochG comprising an alternating, interleaved acoustic complex of 250- and 500-Hz stimuli was used to elicit cochlear microphonics (CMs) during insertion.
Article Synopsis
- The study aimed to analyze the relationship between electrocochleography (ECochG) responses from the promontory and other intracochlear sites, as well as their correlation with postoperative speech-perception performance in cochlear implant (CI) recipients.
- Strong linear correlations were found between promontory ECochG responses and those measured at the round window and other intracochlear locations, indicating consistency in response amplitudes across different sites.
- The findings suggest that promontory ECochG can significantly predict CI performance, highlighting its potential clinical application in preoperative assessments for better patient outcomes.
Although significant progress has been made in understanding outcomes following cochlear implantation, predicting performance remains a challenge. Duration of hearing loss, age at implantation, and electrode positioning within the cochlea together explain ~ 25% of the variability in speech-perception scores in quiet using the cochlear implant (CI). Electrocochleography (ECochG) responses, prior to implantation, account for 47% of the variance in the same speech-perception measures.
View Article and Find Full Text PDFObjective: Describe early hearing preservation (HP) cochlear implantation (CI) outcomes using a new slim lateral wall electrode (SLWE).
Study Design: Prospective cohort study.
Setting: Tertiary referral center.
Catchment Profile of Large Cochlear Implant Centers in the United States.
Otolaryngol Head Neck Surg
September 2022
Objective: To characterize the catchment area and patient profile of large cochlear implant (CI) centers in the United States.
Study Design: Multi-institutional retrospective case series.
Setting: Tertiary referral CI centers.
Objective: To evaluate the impact of different open set sentence recognition tests in quiet, +10 dB signal to noise ratio (SNR), and +5 dB SNR in adult cochlear implant (CI) recipients above and below 65 years of age.
Study Design And Setting: Multi-institution, prospective, non-randomized, single-subject repeated measures design.
Patients: Ninety six adults more than or equal to 18 years old with postlingual bilateral sensorineural hearing loss.
Background: Best practice guidelines for verifying fittings of bone-anchored hearing devices (BAHD) recommend using aided sound-field thresholds (ASFT), but express caution regarding the variables impacting obtaining valid and reliable ASFTs.1 Recently, a skull simulator was introduced to facilitate programming BAHD devices in force level (FL) to desired sensation level-bone conduction devices (skull simulator/DSL-BCD)2 3 targets in a hearing aid analyzer. Currently, no evidence is available reporting if differences in measured FL using the manufacturer first-fit (FF) and word recognition in quiet, sentence reception threshold in noise, and subjective outcomes are present for a BAHD programmed using ASFT versus programmed using skull simulator/DSL-BCD targets.
View Article and Find Full Text PDFObjective: Describe audiologic outcomes in hearing preservation (HP) cochlear implant candidates using a slim modiolar electrode (SME).
Study Design: Retrospective.
Setting: Tertiary referral center.