Publications by authors named "Cameron Schluter"
Article Synopsis
- PPM1D is a phosphatase linked to cancer that negatively regulates the DNA damage response and p53, and its inhibition can slow tumor growth and enhance the effectiveness of cancer treatments.
- * Researchers conducted a high-throughput screen for new allosteric inhibitors of PPM1D, developing various assays to explore its biology and potential as a drug target.
- * The findings reveal that the effects of inhibiting PPM1D differ from those of existing therapies, suggesting unique therapeutic opportunities for targeting PPM1D in cancer treatment.
Article Synopsis
- PPM1D is a phosphatase frequently activated in cancer, especially in therapy-related myeloid neoplasms, but its role in blood cell formation and tumor growth is not fully understood.
- Research using conditional mouse models reveals that PPM1D is crucial for hematopoiesis by influencing the fitness and self-renewal of hematopoietic stem cells, and while it grants some resistance to chemotherapy, it's less effective than losing p53.
- Loss of PPM1D makes leukemias more sensitive to chemotherapy, and inhibiting it may be beneficial across various cancers, suggesting that targeting PPM1D could be a promising new therapy for cancer treatment without major side effects in mice.
For cancer patients undergoing treatment who may be at higher risk of COVID-19, access to high-quality online health information (OHI) may be of particular importance amidst a plethora of harmful medical misinformation online. Therefore, we assessed the readability and quality of OHI available for various cancer types and treatment modalities. Search phrases included "cancer radiation COVID," "cancer surgery COVID," "cancer chemotherapy COVID," and "cancer type COVID," for the fourteen most common cancer types (e.
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