Association Between Nail Type and Aseptic Revision Risk After Cephalomedullary Nailing for Hip Fracture.

Background: Although the majority of intertrochanteric femoral fractures in the United States are now treated with cephalomedullary nailing, it remains uncertain whether differences in clinical performance by nail type exist. The purpose of this study was to compare the aseptic revision rates associated with the 3 most commonly utilized cephalomedullary nails in the United States today: the Gamma nail (Stryker), the INTERTAN (Smith+Nephew), and the Trochanteric Fixation Nail/Trochanteric Fixation Nail Advanced (TFN/TFNA; DePuy Synthes).

Methods: Using an integrated health-care system's hip fracture registry, patients ≥60 years of age who were treated with 1 of these 3 commonly used cephalomedullary nail devices were identified.

Treatment of Intertrochanteric Femur Fractures with Long versus Short Cephalomedullary Nails.

Context: Prior studies regarding indications for long vs short cephalomedullary nails in the treatment of intertrochanteric fractures had limited sample sizes and follow-up, suggesting a need for further investigation.

Objective: To evaluate the association between cephalomedullary nail length and outcomes for the treatment of intertrochanteric femur fractures.

Design: Cohort study using Kaiser Permanente's Hip Fracture Registry.

Models of hemorrhagic shock: differences in the physiological and inflammatory response.

Introduction: The hemorrhagic shock (HS) model is commonly used to initiate a systemic post-traumatic inflammatory response. Numerous experimental protocols exist and it is unclear how differences in these models affect the immune response making it difficult to compare results between studies. The aim of this study was to compare the inflammatory response of different established protocols for volume-controlled shock in a murine model.

Analysis of migration of press-fit porous-coated acetabular components with medial lucencies using Ein-Bild-Roentegen-Analyse.

A total of 136 patients who underwent total hip arthroplasty (154 hips) with press-fit acetabular components were evaluated for the presence of medial radiographic lucencies. Thirty patients (22.1%) demonstrated radiolucencies greater than 1 mm in zone 2 on initial postoperative films.

Fractures of the calcaneal tuberosity treated with suture fixation through bone tunnels.

Fractures of the calcaneal tuberosity, although rare, present a challenge for the treating surgeon. The goal of treatment is restoration of function of the gastrocnemius-soleus complex and the Achilles tendon. These fractures often occur in diabetics and elderly osteoporotic patients and therefore fixation of the displaced fragment is difficult.

Correlation of angulation on initial and healed radiographic views of surgical humerus neck fractures.

This retrospective study evaluated the correlation of the angulation on initial and healed radiographs of displaced surgical humerus neck fractures treated nonoperatively, with emphasis on the initial axillary view. Thirty-six patients with displaced isolated surgical humerus neck fractures were treated nonoperatively to union. Fracture angulation of the injury and healed views were measured.

Use of circular external fixation to maintain foot position during free tissue transfer to the foot and ankle.

Limb salvage techniques of traumatized extremities using free-tissue transfer and microsurgical techniques have become standard reconstructive methods. To our knowledge there is no published data on the incidence or likelihood of equinus following free tissue transfer about the ankle, although in our experience we have perceived an unacceptable incidence of equinus following free tissue transfers about the ankle and therefore initiated prophylactic ring fixation across the ankle. Fourteen patients were placed in circular external fixation spanning the ankle at the time of free tissue transfer for a mean of 12 weeks (Median 7 weeks, Range 6-28 weeks).

Tumor necrosis factor alpha activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors.

Objective: Tumor necrosis factor alpha (TNFalpha) blockade provides substantive reduction of the symptoms of rheumatoid arthritis (RA). While the biologic actions of TNFalpha have been well characterized in immune and synovial cells, which are known to be major contributors to the progression of cartilage destruction in RA, the current studies were designed to assess the direct effects of TNFalpha on chondrocytes.

Methods: We examined the expression of several groupings of messenger RNA (mRNA) that define key biologic pathways that have previously been associated with either the general actions of TNFalpha or cartilage destruction, in murine articular chondrocytes isolated from wild-type mice and TNFalpha receptor-null (p55/p75(-/-)) mice.