Long-Term Mortality After Charcot Reconstruction.

Charcot neuroarthropathy is a complicated phenomenon with the potential to cause significant deformity, morbidity, and mortality. Costs associated with Charcot-related complications are substantial, with thousands of amputations occurring annually. The purpose of this study was to retrospectively review a single surgeon's experience and record the 10-year mortality rate among patients after Charcot reconstruction at a single institution between 2007 and 2013.

Do animal husbandry operations contaminate groundwater sources with antimicrobial resistance: systematic review.

Antimicrobial resistance (AMR) is a critical global health concern. Animal husbandry operations are AMR hotspots due to heavy antibiotic use and dissemination of animal waste into the environment. In this systematic review, we examined the impact of swine, poultry, and cattle operations on AMR in groundwater.

Safety and Complication Rate of Ring External Fixation in the Foot and Ankle.

External fixation is a powerful tool for foot and ankle surgeons. Currently, there is no consensus on true complication rate. The purpose of this study was to report our institution's complication rate of ring external fixation performed by a single surgeon.

Kidney collecting duct cells make vasopressin in response to NaCl-induced hypertonicity.

Vasopressin has traditionally been thought to be produced by the neurohypophyseal system and then released into the circulation where it regulates water homeostasis. The questions of whether vasopressin could be produced outside of the brain and if the kidney could be a source of vasopressin are raised by the syndrome of inappropriate antidiuretic hormone secretion (vasopressin). We found that mouse and human kidneys expressed vasopressin mRNA.

Podcasting in Medicine: A Review of the Current Content by Specialty.

Background Podcasts and their use in medical education is growing and becoming more popular, all while not knowing what podcasts are available for each specialty. Objectives To ascertain the number of podcasts available by specialty and collect basic characteristics of each podcast.  Methods This was a Google-based, investigational study of medical podcasts by specialty undertaken by all authors from January to June 2019.

Birth Planning in Uncertain or Life-Limiting Fetal Diagnoses: Perspectives of Physicians and Parents.

Providers often use birth plans to document parents' wishes for their fetus with a life-limiting condition. The objective of the study was to (1) discover important components of a birth plan for parents and providers who carry them out, and (2) understand the experience of parents and providers with birth plans. The study design involves mixed-methods, descriptive, exploratory survey.

Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.

Renal fibrosis is the pathological hallmark of chronic kidney disease (CKD) and manifests as glomerulosclerosis and tubulointerstitial fibrosis. Reactive oxygen species contribute significantly to renal inflammation and fibrosis, but most research has focused on superoxide and hydrogen peroxide (HO). The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), and peroxidasin (PXDN) uniquely metabolize HO into highly reactive and destructive hypohalous acids, such as hypobromous and hypochlorous acid.

"There but not there": Imagined bonds with siblings never known.

Continuing a bond after a loved one's death is considered typical and healthy. However, such a bond can continue symbolically only if it existed in the first place. What of indirect grievers, those who never knew the decedent? The authors describe bonds between individuals who did not have a living relationship to begin with, a concept referred to as imagined bonds.

Misconceptions about health and disease prevention behaviors of rural Appalachian Americans.

Background: Appalachia is one of the unhealthiest regions in the United States due to poor disease prevention behaviors.

Objective: Determine if self-perceived health of rural Appalachians is related to participation in disease prevention behaviors.

Methods: Rural Appalachian adults (n=437) were surveyed regarding their self-perceived health and disease prevention behaviors.