Defluoroalkylation of Trifluoromethylarenes with Hydrazones: Rapid Access to Benzylic Difluoroarylethylamines.

Here, we report an efficient and modular approach toward the formation of difluorinated arylethylamines from simple aldehyde-derived -dialkylhydrazones and trifluoromethylarenes (CF-arenes). This method relies on selective C-F bond cleavage via reduction of the CF-arene. We show that a diverse set of CF-arenes and CF-heteroarenes react smoothly with a range of aryl and alkyl hydrazones.

Synthesis of Spirocyclic Piperidines by Radical Hydroarylation.

Reported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achieve formation of aryl radical species. Regioselective cyclization followed by hydrogen-atom transfer affords a range of complex spiropiperidines.

Radical α-C-H Cyclobutylation of Aniline Derivatives.

A catalytic system has been developed for the direct alkylation of α-C-H bonds of aniline derivatives with strained C-C σ-bonds. This method operates through a photoredox mechanism in which oxidative formation of aminoalkyl radical intermediates enables addition to a bicyclobutane derivative, giving rise to α-cyclobutyl -alkylaniline products. This mild system proceeds through a redox- and proton-neutral mechanism and is operational for a range of substituted arylamine derivatives.

One-pot synthesis of a ceria-graphene oxide composite for the efficient removal of arsenic species.

Arsenic contamination has posed a health risk to millions of people around the world. In this study, we describe a simple and facile one-step hydrothermal synthesis of a ceria-graphene oxide (ceria-GO) composite for the efficient removal of arsenic species. The prepared ceria-GO composite materials exhibited almost complete (over 99.