Publications by authors named "Cameron Finlayson"
Article Synopsis
- - The nervous system's complexity relies on how individual neurons manage dendritic branching, which is crucial for their structure and function.
- - The protein KNL-1, typically known for its role in cell division, also regulates dendrite branching in specific neurons by controlling the actin cytoskeleton and preventing excessive growth.
- - Loss of KNL-1 leads to significant changes in the neuron’s structure, demonstrating its essential role in maintaining proper dendrite architecture and highlighting new insights into nervous system development.
The KMN (Knl1/Mis12/Ndc80) network at the kinetochore, primarily known for its role in chromosome segregation, has been shown to be repurposed during neurodevelopment. Here, we investigate the underlying neuronal mechanism and show that the KMN network promotes the proper axonal organization within the head nervous system. Postmitotic degradation of KNL-1, which acts as a scaffold for signaling and has microtubule-binding activities at the kinetochore, led to disorganized ganglia and aberrant placement and organization of axons in the nerve ring - an interconnected axonal network.
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