Purpose: Venous thromboembolism (VTE) is a well-known problem in patients with intracranial tumors, especially high-grade gliomas. Optimal management of VTE complications is critical given that the development of deep vein thrombosis (DVT) and/or pulmonary embolism can exacerbate medical comorbidities and increase mortality. However, little is known about the optimum time to initiate post-operative anticoagulant prophylaxis.
View Article and Find Full Text PDFBackground: The inferior temporal gyrus (ITG) is known to be involved in high-cognitive functions, including visual and language comprehensions and emotion regulation. A detailed understanding of the nature of association fibers could significantly improve postoperative morbidity related to declining capacity. Through diffusion spectrum imaging-based fiber tracking, we have characterized these connections on the basis of their relationships to other cortical areas.
View Article and Find Full Text PDFPurpose: Minimizing post-operational neurological deficits as a result of brain surgery has been one of the most pertinent endeavours of neurosurgical research. Studies have utilised fMRIs, EEGs and MEGs in order to delineate and establish eloquent areas, however, these methods have not been utilized by the wider neurosurgical community due to a lack of clinical endpoints. We sought to ascertain if there is a correlation between graph theory metrics and the neurosurgical notion of eloquent brain regions.
View Article and Find Full Text PDFA unique challenge in some brain tumor patients is the fact that tumors arising in certain areas of the brain involve the neural structures of consciousness or alertness, limiting the patient's ability to participate in rehabilitation following surgery. A critical question is whether neurostimulant therapy can help patients participate in rehabilitation efforts. We performed a retrospective review of all patients undergoing brain tumor surgery by the senior author from 2012 to 2018.
View Article and Find Full Text PDFIntroduction: Graph theory is a promising mathematical tool to study the connectome. However, little research has been undertaken to correlate graph metrics to functional properties of the brain. In this study, we report a unique association between the strength of cortical regions and their function.
View Article and Find Full Text PDFBackground: The basal ganglia and thalamus are uncommon locations for infiltrating gliomas. Tumors here are usually managed with biopsy and adjuvant therapy, with relatively poor results. Rarely do patients undergo extensive surgical intervention.
View Article and Find Full Text PDFBackground: Arterial disruption during brain surgery can cause devastating injuries to wide expanses of white and gray matter beyond the tumor resection cavity. Such damage may occur as a result of disrupting blood flow through en passage arteries. Identification of these arteries is critical to prevent unforeseen neurologic sequelae during brain tumor resection.
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