Publications by authors named "Cameron A Czerpak"
Article Synopsis
- The study aimed to measure biomechanical strains in the lamina cribrosa of human eyes during increases in intraocular pressure (IOP) using optical coherence tomography (OCT) imaging.
- After applying swim goggles to raise IOP, significant strains were observed in glaucoma patients, with increases linked to worse visual function and complications.
- The findings suggest that biomechanical responses in the optic nerve head could serve as a noninvasive biomarker for assessing glaucoma damage.
Objective: To measure the remodeling of the lamina cribrosa (LC) years after intraocular pressure (IOP) lowering by suturelysis.
Design: Cohort study.
Participants: Glaucoma patients were imaged 20 minutes after laser suturelysis after trabeculectomy surgery and at their follow-up appointment 1 to 4 years later (16 image pairs; 15 persons).
Objective: To measure mechanical strain of the lamina cribrosa (LC) after intraocular pressure (IOP) change produced one week after a change in glaucoma medication.
Design: Cohort study.
Participants: Adult glaucoma patients (23 eyes, 15 patients) prescribed a change in IOP-lowering medication.
The lamina cribrosa (LC) is a connective tissue in the optic nerve head (ONH). The objective of this study was to measure the curvature and collagen microstructure of the human LC, compare the effects of glaucoma and glaucoma optic nerve damage, and investigate the relationship between the structure and pressure-induced strain response of the LC in glaucoma eyes. Previously, the posterior scleral cups of 10 normal eyes and 16 diagnosed glaucoma eyes were subjected to inflation testing with second harmonic generation (SHG) imaging of the LC and digital volume correlation (DVC) to calculate the strain field.
View Article and Find Full Text PDFObjective: To measure biomechanical strains in the lamina cribrosa (LC) of living human eyes with intraocular pressure (IOP) lowering.
Design: Cohort study.
Participants: Patients with glaucoma underwent imaging before and after laser suturelysis after trabeculectomy surgery (29 image pairs; 26 persons).