Publications by authors named "Cameran Owens"
Background: Sociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.
Methods: In a prospective, multi-institutional study, adult PwCF completed the 22-Question SinoNasal Outcome Test (SNOT-22), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R).
Article Synopsis
- The study aimed to identify factors that predict improvement in chronic rhinosinusitis symptoms, measured by the SNOT-22, after initiating highly effective modulator therapy in adults with cystic fibrosis.
- Data from 184 participants showed that worse initial SNOT-22 scores, having the F508del mutation, and not having prior modulator therapy were linked to greater symptom improvement post-therapy.
- The minimal clinically important difference (MCID) for the SNOT-22 in this population was determined to be 8.5 points, indicating significant symptom improvement, and the test demonstrated strong internal consistency.
Background: Chronic rhinosinusitis (CRS) is common in people with cystic fibrosis (PwCF). Rhinologic symptom prioritization and areas that influence CRS treatment choices, including pursuing endoscopic sinus surgery (ESS), remain understudied.
Methods: Adult PwCF + CRS were enrolled at eight centers into a prospective, observational study (2019-2023).
Determining the minimal clinically important difference for the questionnaire of olfactory disorders in people with cystic fibrosis and factors associated with improvement after highly effective modulator therapy.
Int Forum Allergy Rhinol
June 2024
Introduction: Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF). The Questionnaire of Olfactory Disorders (QOD) is a validated instrument that evaluates olfactory-specific quality-of-life. The QOD minimal clinically important difference (MCID) and factors associated with olfactory improvement after elexacaftor/tezacaftor/ivacaftor have not been determined for PwCF.
View Article and Find Full Text PDFBackground: Comorbid chronic rhinosinusitis (CRS) remains unresolved for many people with cystic fibrosis (PwCF). While highly effective modulator therapy improves quality-of-life and symptom severity, the impact of this intervention and other factors associated with pursuing endoscopic sinus surgery (ESS) remains understudied.
Methods: Adult PwCF + CRS were enrolled into a prospective, observational, multi-institutional study.