The State and the Citizen: Overview of a complex relationship from a paradigmatic perspective.

Notwithstanding the huge literature on studies, both definition and method have always been subject of intense debate. This debate is still open and equally intense despite two millennia of philosophical and methodological attempts to define the is, to describe the state works, and does it work. As times, geopolitical contexts, and human action have shaped the historical and conceptual trajectory of polity studies, the theories as well as methodologies have increasingly emphasized focus on individuals, (political) cultures, power, and relationships both between individuals and between individuals and the .

[When home become breathtaking].

We spend most of our time indoor and mainly at home. Thermal insulation has greatly improved in the last decades, thus leading to deficiency in ventilation and poor indoor air quality. Many studies suggest that there is a link between respiratory diseases and various indoor air pollutants such as moulds, allergens, volatile organic compounds, combustible smoke, house dust mite, radon or asbestos.

Hepatosplenomegaly, pneumopathy, bone changes and fronto-temporal dementia: Niemann-Pick type B and SQSTM1-associated Paget's disease in the same individual.

Data from exome sequencing show that a proportion of individuals in whom a genetic disorder is suspected turn out to have not one, but two to four distinct ones. This may require an evolution in our diagnostic attitude towards individuals with complex disorders. We report a patient with splenomegaly, pneumopathy, bone changes and fronto-temporal dementia (FTD).