Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus.

Run-to-run control has been applied to several traditional batch processes in the chemical industry. The 24-h cycle of eating meals, measuring blood glucose concentrations, and delivering the correct insulin bolus, with the goal of achieving the optimal blood glucose profile, can be viewed in the same spirit as traditional batch processes such as emulsion polymerization. In this paper, we aim to exploit the "repetitive" nature of the insulin therapy of people with Type 1 diabetes.

Run-to-run control of meal-related insulin dosing.

Background: This study was designed to determine if it was feasible to use a run-to-run algorithm to improve postprandial glucose concentrations in individuals with type 1 diabetes mellitus (T1DM).

Methods: Fourteen subjects were recruited for this 10-week study. During the initial phases of the study, the following information was derived for each subject: basal insulin infusion rates, insulin-to-carbohydrate ratios, insulin correction factors for hyperglycemia, and insulin sensitivities.