Quantitative analysis of urinary daidzein and equol by gas chromatography after solid-phase extraction and high-performance liquid chromatography.

Daidzein and its main metabolite equol are isoflavone phytoestrogens. Several studies have suggested that intake of an isoflavone-rich diet may prevent hormone-related cancer and estrogen-related disorders (cardiovascular disease, osteoporosis and menopausal symptoms). To better understand the role of isoflavones in preventing such severe disease, several methods have been developed to measure these compounds in biological fluids.

[Cryosurgery of basal cell carcinoma: a study of 358 patients].

Introduction: Cryosurgery is a well-established therapeutic modality for basal cell carcinoma. We report herein an important series of basal cell carcinoma treated by cryosurgery, with a five year cure rate evaluation.

Patients And Method: Retrospective study with 395 basal cell carcinomas (over 358 patients - sex ratio H/F: 0.

Urinary 5 alpha-androstanediol and 5 beta-androstanediol measurement by gas chromatography after solid-phase extraction and high-performance liquid chromatography.

Urinary androstanediol measurement, often in association with other androgens, is commonly used to support the clinical diagnosis of idiopathic hirsutism. In addition, androgen excess has been shown to be the endocrine abnormality which characterizes patients with breast cancer. We recently developed a method for the measurement of urinary testosterone employing solid-phase extraction and HPLC purification before quantitative measurement by gas chromatography.

[Lichenoid contact dermatitis from the ink of a red pen].

Introduction: Numerous cutaneous inflammatory reactions have been reported in literature, after using red dyes; most of them are lichenoid reactions and occur after tattooing. Few reports have mentioned inflammatory complications after using red ink.

Case Report: A 21-year-old woman was examined for papular erythematous, pruritic lesions on the back of her left hand.

[Palmoplantar filiform parakeratotic hyperkeratosis and digestive adenocarcinoma].

Introduction: There are very few observations of filiform palmo-plantar hyperkeratosis reported. Nevertheless it's worth knowing this entity for his potential association with a visceral neoplasia.

Case Report: We report the first case of filiform palmo-plantar hyperkeratosis associated with a digestive adenocarcinoma and a polycystic kidney disease.

Erythema multiforme due to pyrazinamide.

Drug-induced erythema multiforme is reported with many antimicrobial and antipyretic medications. We present one patient who experienced erythema multiforme and urticaria after administration of pyrazinamide for treatment of cutaneous tuberculosis. The side-effects of pyrazinamide include hepatic or dermatologic disorders, but erythema multiforme has not yet, to our knowledge, been described.

[Unilateral gustatory flushing syndrome in a child].

Background: Auriculo-temporal syndrome is rarely seen in children: it is sometimes considered as secondary to an obstetrical injury.

Case Report: A 2.5 year-old boy was examined because he suffered from post-prandial flushing of the right cheek for 2 years.

[Cutaneous metastases of melanoma localized on the cicatrix at the site of flap taking].

Introduction: We report one case of melanoma cutaneous metastases strictly localized on a skin graft donor site distant from the tumor site.

Case Report: A patient with a shoulder melanoma was treated by surgery. A split-thickness skin graft was taken from a thigh to cover the raw area.

[Vulvar lymphangiectasis 14 years after treatment for epidermoid carcinoma of the cervix. Treatment with cryosurgery].

Introduction: Lymphangiectasia are different from lymphangioma because they arise following damage to the deeper lymphatic vessels. No clinical or histological features are known to distinguish lymphangioma from lymphangiectasia.

Case Report: We report a case of vulvar lymphangiectasia occurring 14 years after therapy of squamous carcinoma of the cervix (surgery and post-operative radiotherapy).

[Bazex paraneoplastic acrokeratosis. Treatment with acitretin].

Introduction: Bazex paraneoplastic acrokeratosis remains a therapeutic challenge when the cancer cannot be treated. We report the third patient in which a complete clearance of the lesions was obtained with oral acitretine.

Case Report: A 67 year-old patient had Bazex paraneoplastic acrokeratosis.

[Acute febrile pustular and bullous neutrophilic dermatosis (Sweet syndrome) disclosing acute myeloblastic leukemia].

We report a patient with Sweet's syndrome (acute febrile neutrophilic dermatosis) revealing an acute myelogenous leukemia. About 10% of Sweet's syndromes are associated with a malignant disease that they can reveal. Among those, hemopathies are the most frequent, and 42% are myelogenous leukemia.

[Gianotti-Crosti acrodermatitis. Description of a case of rare etiology].

Originally described in 1955, papular acrodermatitis is considered a rare disease whose manifestations are mainly cutaneous. The disease is characteristically associated to a non icteric hepatitis with B serologic tests positive. We recently observed a case whose etiology is unusual and, therefore, in our opinion worth of a brief description.

Non-opposable triphalangeal thumb in an Italian family.

This report describes a family with bilateral non-opposable triphalangeal thumb, bringing to two the number of families with this autosomal dominant disorder.

[Difficult diagnosis in a case of hematuria (Berger's disease)].

A seven years old boy presented with gross hematuria associated with clots and transitory renal insufficiency. The urinary sediment showed only monomorphic red blood cells. Subsequently urinary sediment completely modified: namely only dysmorphic red blood cells and hyaline granular casts were found and within a week renal function become normal.

[Facio-auriculo-vertebral syndrome: description of a case].

The authors report the case of a fourteen months old girl who presented with emisomal, uropoietic and vertebral anomalies associated with neurologic handicap. These features can be considered characteristic of facio-auriculo-vertebral spectrum. This syndrome was not frequently described in Italian pediatric literature.

[A case of septic arthritis with a peculiar clinical presentation].

The authors report a case of tibial-tarsal septic arthritis caused by a Group A Beta Haemolytic Streptococcus. The primitive pathologic process was an erysipelas with an unusual localization originally of difficult interpretation.

Dermatitis herpetiformis and nephrotic syndrome.

A 6 year old girl is reported who suffered from dermatitis herpetiformis, nephrotic syndrome and celiac disease. HLA typing in our patient disclosed the HLA antigens B8 and DW3, which are known to be frequently associated with nephrotic syndrome, celiac disease and dermatitis herpetiformis. In the literature six cases have been reported of the association of glomerulonephritis and dermatitis herpetiformis.