Publications by authors named "Calvin Wl Chin"
Biomarkers in the evaluation of cardiac involvement in systemic sclerosis.
Rheumatol Immunol Res
June 2024
Systemic sclerosis is a multisystemic disease for which the heart can be affected leading to cardiac complications and mortality. Up to 80% of patients with systemic sclerosis have cardiac involvement with varying levels of severity. Several molecules have been identified that can be used as markers of cardiac involvement.
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- Heart failure (HF) and diabetes worsen each other’s outcomes, and this study evaluated global longitudinal strain (GLS) as a prognostic marker in HF patients with diabetes.
- In a study of 315 HF patients, those with diabetes showed significantly worse cardiovascular indicators, such as higher late gadolinium enhancement rates and elevated biomarker levels compared to non-diabetic patients.
- The results indicated that patients with diabetes not only had poorer health indicators but also a worse prognosis, with GLS and soluble ST2 biomarkers emerging as independent prognostic factors for adverse outcomes.