Publications by authors named "Calvin C O Man"
Purpose: To evaluate guideline adherence and variation in the recommended use of neoadjuvant chemotherapy (NAC) and the effects of this variation on survival in patients with non-metastatic muscle-invasive bladder cancer (MIBC).
Patients And Methods: In this nationwide, Netherlands Cancer Registry-based study, we identified 1025 patients newly diagnosed with non-metastatic MIBC between November 2017 and November 2019 who underwent radical cystectomy. Patients with ECOG performance status 0-1 and creatinine clearance ≥ 50 mL/min/1.
Article Synopsis
- * A study on 15 pediatric patients with de novo SETD1A variants found these mutations resulted in DNA damage repair issues and hinted at loss-of-function effects, which are vital for understanding the underlying mechanisms of these disorders.
- * Research using Drosophila demonstrated that the SETD1A gene is necessary for normal memory function in neurons, suggesting its role extends beyond early development to impact cognitive processes in adulthood.