Normative measurements of the frontal nerve by magnetic resonance imaging in an Australia cohort.

Purpose: To report the normative dimensions of the frontal nerve (FN) on fat-suppressed suppressed gadolinium (fs-gad) enhanced magnetic resonance imaging (MRI).

Method: A retrospective cohort study of patients who underwent coronal fs-gad T1-weighted MRI. Orbits were excluded if there was unilateral or bilateral pathology of the FN or optic nerve sheath (ONS), incomplete MRI sequences, poor image quality or indiscernible FN on radiological assessment.

Lacrimal gland enlargement in thyroid eye disease.

Purpose: This study aimed to investigate lacrimal gland (LG) enlargement in thyroid eye disease (TED) patients on magnetic resonance imaging (MRI).

Methods: A retrospective review was conducted on TED patients who had undergone fat-suppressed contrast-enhanced T1-weighted MRI of the orbits. The lacrimal gland was segmented on OsiriX in consecutive axial and coronal slices to determine its volume.

Normative Measurements of the Infraorbital Nerve by Magnetic Resonance Imaging in an Australia Cohort.

Purpose: To report the normative dimensions of the infraorbital nerve on fat-suppressed gadolinium-enhanced MRI and correlate with patient demographics in an Australian cohort.

Methods: A retrospective review of patients who underwent coronal fat-suppressed gadolinium T1-weighted MRI from September 2021 to December 2023. One hundred sixty-eight orbits were included.

Artificial intelligence to automate assessment of ocular and periocular measurements.

Purpose: To develop and validate a deep learning facial landmark detection network to automate the assessment of periocular anthropometric measurements.

Methods: Patients presenting to the ophthalmology clinic were prospectively enrolled and had their images taken using a standardised protocol. Facial landmarks were segmented on the images to enable calculation of marginal reflex distance (MRD) 1 and 2, palpebral fissure height (PFH), inner intercanthal distance (IICD), outer intercanthal distance (OICD), interpupillary distance (IPD) and horizontal palpebral aperture (HPA).

Artificial Intelligence Applied to Electrical and Non-Invasive Hemodynamic Markers in Elderly Decompensated Chronic Heart Failure Patients.

Objectives: The first aim of this study was to assess the predictive power of Tend interval (Te) and non-invasive hemodynamic markers, based on bioimpedance in decompensated chronic heart failure (CHF). The second one was to verify the possible differences in repolarization and hemodynamic data between CHF patients grouped by level of left ventricular ejection fraction (LVEF). Finally, we wanted to check if repolarization and hemodynamic data changed with clinical improvement or worsening in CHF patients.

Recurrent inferior oblique myositis and its outcomes.

This report presents a unique case of recurrent idiopathic inferior oblique myositis (IOM) with a focus on clinico-radiological characteristics and histological features. A woman in her early 40s presented with a third episode of IOM following a 12-year period of quiescence. The first two episodes were characterised by unilateral IOM with rapid resolution following oral prednisone treatment.

Extraocular muscle enlargement and proptosis in carotid cavernous fistulas.

Purpose: To evaluate the prevalence and pattern of extraocular muscle enlargement and proptosis in patients with carotid cavernous fistulas (CCF).

Methods: We conducted a retrospective study on patients with digital subtraction angiography (DSA) confirmed CCFs with neuroimaging (computed tomography or magnetic resonance imaging) performed prior to the DSA. The maximum extraocular muscle diameters were recorded.

Sex Differences in Repolarization Markers: Telemonitoring for Chronic Heart Failure Patients.

Unlabelled: Aging and chronic heart failure (CHF) are responsible for the temporal inhomogeneity of the electrocardiogram (ECG) repolarization phase. Recently, some short period repolarization-dispersion parameters have been proposed as markers of acute decompensation and of mortality risk in CHF patients. Some important differences in repolarization between sexes are known, but their impact on ECG markers remains unstudied.

Electrocardiographic and other Noninvasive Hemodynamic Markers in Decompensated CHF Patients.

Acutely decompensated chronic heart failure (adCHF) is among the most important causes of in-hospital mortality. R-wave peak time (RT) or delayed intrinsicoid deflection was proposed as a risk marker of sudden cardiac death and heart failure decompensation. Authors want to verify if QR interval or RT, obtained from 12-lead standard ECG and during 5-min ECG recordings (II lead), could be useful to identify adCHF.

Time and Frequency Repolarization Domains in Elderly Candidates to Transcatheter Aortic Valve Replacement.

Background And Aim: Aortic valve stenosis (AVS) is a well-known risk factor for sudden cardiac death. Therefore, some non-invasive, electrocardiographic markers are capable to stratify the risk of sudden death at rest and during light mental challenge [mini-mental state examination (MMSE) administration].

Method: We compared short period RR, QT and Te intervals variability in 42 candidates to and 12 age-matched hypertensive control patients at rest and during mental challenge.

Normal periocular anthropometric measurements in an Australian population.

Purpose: To report the normative ocular and periocular anthropometric measurements in an Australian cohort and investigate how these may be affected age, gender, and ethnicity.

Methods: Prospective study of patients presenting to the Royal Adelaide Hospital. Patient with orbital or eyelid disease, previous surgery, craniofacial abnormalities, pupil abnormalities, strabismus, and poor image quality was excluded.

Noninvasive Hemodynamic Monitoring in Advanced Heart Failure Patients: New Approach for Target Treatments.

Using bio-impedance to deduce some hemodynamic parameters combined with some short-term ECG temporal dispersion intervals, and measuring myocardial depolarization, intraventricular conduction, and repolarization. A total of 65 in-hospital patients (M/F:35/30) were enrolled, 39 with HFrEF and 26 HFpEF, in New York Heart Association (NYHA) class IV. Stroke volume (SVI), cardiac indexes (CI), left ventricular ejection fraction (LVEFBIO), end diastolic volume (LV-EDV), and other systolic and diastolic parameters were noninvasively obtained at enrollment and at hospital discharge.

Short-Period Temporal Dispersion Repolarization Markers in Elderly Patients with Decompensated Heart Failure.

Objectives: Aging and chronic heart failure (CHF) are responsible for the temporal inhomogeneity of electrocardiogram (ECG) repolarization phase. In the past, short period repolarization-dispersion parameters were used as makers of mortality risk in different heart diseases, yet. Aim of this work was to evaluate risk of mortality or worsening condition in CHF elderly subjects by mean of these repo-larization variables.

5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream.

Background: No studies have evaluated the effectiveness of 5-ASA against oxidative DNA damage in experimental models of diversion colitis.

Aim: To evaluate the effects of 5-ASA against oxidative DNA damage in an experimental model of diversion colitis.

Methods: Twenty-six Wistar rats were divided into two groups corresponding to sacrifice at 2 or 4 weeks after fecal diversion of the left colon by means of proximal colostomy and distal mucosa fistula.

Hepatocyte growth factor receptor, c-Met, in human embryo salivary glands. An immunohistochemical study.

Salivary gland morphogenesis involves complex, coordinated events that include epithelial-mesenchymal interactions. Mesenchymal-epithelial transition factor (c-Met) is the hepatocyte growth factor (HGF) receptor. The latter is a hepatotropic factor originally identified in rat serum and platelets.

Immunolocalization of hepatocyte growth factor receptor, c-Met, in human fetal tooth germ.

To evaluate c-Met expression in human tooth germ development. An immunohistochemical study on c-Met expression in tooth germs of 8 human fetus between the 7th and 9th week. In the Bud stage C-Met immunopositivity was, moderately to strongly, detected both in the inner and the outer epithelium of the enamel organ.

Bitumen products induce skin cell apoptosis in chronically exposed road pavers.

Background: Worker's exposure to bitumen fumes, via inhalation and skin contamination, is related to adverse effects including an increased risk of lung, stomach and non-melanoma skin cancers and leukaemia. The two major mechanisms regulating apoptosis include the mitochondria-mediated intrinsic pathway and the extrinsic pathway induced by death signalling ligands. In a previous study, we showed activation of apoptosis-regulating proteins BAX and BCL-2 in road pavers chronically exposed to bitumen fumes.

Immunolocalization of CD44s in human teeth.

CD44s (standard form) is an integral membrane glycoprotein, which plays an important role in both cell-cell and cell-substrate adhesion. Few studies have demonstrated that CD44s and its isoforms are involved in mediating cell-cell and cell-substrate interactions in the periodontium and surrounding tissues. The present study was undertaken as so little data are available on its presence in human adult hard dental structures.

Expression of vascular endothelial growth factor in human dysfunctional temporomandibular joint discs.

A high density of blood vessels is found in specimens of temporomandibular joint (TMJ) disc at any stage of internal derangement of the joint, but the factors responsible for angiogenesis in the disc have not been described. The purpose here was to investigate, in human TMJ discs, the expression of vascular endothelial growth factor (VEGF), a multifunctional cytokine that contributes to angiogenesis. Specimens, free of significant morphological alterations and with varying degrees of disc tissue degeneration/regeneration, were studied by immunohistochemistry for VEGF in order to correlate immunohistochemical with histopathological findings.

Immunolocalization of vimentin and alpha-smooth muscle actin in dysfunctional human temporomandibular joint disc samples.

The expression of vimentin and alpha-smooth muscle (alpha-SM) actin was examined in 10 human temporomandibular joint (TMJ) disc samples, with internal derangement and in two control specimens, in order to evaluate the phenotypic characteristics of TMJ disc cells in relationship to histological findings. This was accomplished by means of monoclonal antibodies specific for vimentin and alpha-SM actin and immunocytochemical technique. The study, revealed that every disc cell constantly expressed vimentin.

Heat Shock Protein 27 is overexpressed in the skin of bitumen exposed workers. Early observations.

The skin of road pavers is exposed to a large number of compounds such as asphalt, bitumen, amines, polymers, oils, solvents, sand, gravel, crushed rock, mineral wad, ultraviolet light and heat. In order to verify an up-regulation of HSP27, determined by the above mentioned stimuli, we studied, immunohistochemically, the forearm skin of a sample of road pavers occupationally exposed. A total of 25 punch biopsies (3 mm diameters) was obtained from the foream skin of road paver workers (n=16) and a control group (n=5) not exposed.

[Cutaneous histopathologic changes in laboratories working in the processing of petroleum].

Petroleum and its derivatives are a complex mixture of many constituents in varying proportions, such as polycyclic aromatic hydrocarbons, alcohols, ethers and additives. It is well established that petroleum derivatives are absorbed through the skin but exposure has not been quantified. Manifestations of cutaneous exposure vary from squamous cell carcinoma to irritative contact dermatitis such as occurs in the workplace.

[Histomorphology of secondary cartilage in human fetal mandibles].

The aim of this study was to provide a histomorphological analysis of some secondary cartilages of mandible and temporal bone as observed in human fetuses 18-22 weeks old. The behavior of cartilage was studied in both these regions, which were decalcified, cut at 10 mu, stained with Mallory staining and examined by optical microscopy. In mandible symphysis menti and condylar cartilage were described.