Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide.

Background/aim: Prostate cancer is the most common cancer in the Western world. A bi-functional peptide was combined with wingless-related integration site (WNT) inhibitors to determine if there is an additive therapeutic effect when they are used against prostate cancer, since their efficacy has already been proven when used alone.

Materials And Methods: A bi-functional peptide (TP-LYT) was designed with a target domain (LTVSPWY) and a lytic domain (KLAKLAK), and a second peptide with the same lytic domain but a random sequence instead of the target domain was used as a negative control.