Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix.

Metastasis by cancer cells relies upon the acquisition of the ability to evade anoikis, a cell death process elicited by detachment from extracellular matrix (ECM). The molecular mechanisms that ECM-detached cancer cells use to survive are not understood. Striking increases in reactive oxygen species (ROS) occur in ECM-detached mammary epithelial cells, threatening cell viability by inhibiting ATP production, suggesting that ROS must be neutralized if cells are to survive ECM-detachment.

Keeping a breast of recent developments in cancer metabolism.

For decades, it has been recognized that cancer cells display a unique metabolism; specifically, cancer cells have been shown to preferentially utilize glycolysis instead of mitochondrial respiration. This phenomenon is commonly known as the "Warburg effect" after Otto Warburg who first made this observation in 1927. The discovery of the Warburg effect has lead to new methods of detection and differentiation of cancerous tissue and normal tissue.