Publications by authors named "Callen F Feeney"
Article Synopsis
- * A new compound discovered enhances RNA binding in a key component of the spliceosome (U2AF2) and disrupts splicing by blocking assembly at a critical stage.
- * This compound shows potential to selectively kill cells with cancer-related mutations in spliceosomal components, indicating that targeting spliceosome assembly could be an effective treatment strategy.
An essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly at polypyrimidine (Py) signals preceding the major class of 3' splice sites. U2AF1 frequently acquires an S34F-encoding mutation among patients with myelodysplastic syndromes (MDS). The influence of the U2AF1 subunit and its S34F mutation on the U2AF2 conformations remains unknown.
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