- A 30-year-old man with relapsing-remitting multiple sclerosis experienced psoriasiform dermatitis after his second ocrelizumab treatment, which resolved with topical treatments and stopping the medication.
- There is a rising number of reports linking psoriasiform rashes to ocrelizumab use, potentially caused by B-cell depletion and T-cell overregulation.
- Currently, skin-related side effects are not addressed in the risk management plans for anti-CD20 therapies like ocrelizumab in multiple sclerosis patients.
A 62-year-old man attended ophthalmology for a simple ptosis repair. He had a chronic cough, a Horner's syndrome with post-gustatory hyperhidrosis. He was referred to the respiratory and neurology teams.