"I think deprescribing is very needed in our society:" Healthcare Professional Students Perceptions of Deprescribing Education.

Deprescribing is a complex and pivotal process in the healthcare system that requires the involvement of different healthcare professionals, as well as patients and family members. Given the multifaceted healthcare professionals involved in deprescribing, fostering interdisciplinary healthcare teams during the didactic and experiential educational engagement is imperative. Thus, this study aimed to characterize healthcare professional students' opinions on the importance of an interdisciplinary approach to deprescribing during the didactic and experiential components of the curriculum.

Does a black light lens aid in composite removal?

Objective: To evaluate the effectiveness of a black light lens as visual aid in composite restoration removal. Lost tooth structure, residual composite, and removal time were compared for operators with different levels of experience.

Methods: Occlusal preparations in 24 matched-pair extracted molars were etched, bonded, restored with composite, and thermocycled.

Skeletochronology and Paleohistology of (Crocodyliformes, Dyrosauridae) from the Early Paleogene of New Jersey, USA.

The paleohistology of dyrosaurids is known from a small sample, despite being common fossils and representing a rare lineage of crocodylomorphs that survived the Cretaceous-Paleogene extinction. Their lifestyle has been inferred only from sections of the snout, vertebrae, partial femur, and tibia. To improve this, we conducted a skeletochronological and paleohistological study of midshaft cross-sections of both femora and humeri of a nearly complete skeleton.

Background conditions for an urban greenhouse gas network in the Washington, D.C. and Baltimore metropolitan region.

As city governments take steps towards establishing emissions reduction targets, the atmospheric research community is increasingly able to assist in tracking emissions reductions. Researchers have established systems for observing atmospheric greenhouse gases in urban areas with the aim of attributing greenhouse gas concentration enhancements (and thus, emissions) to the region in question. However, to attribute enhancements to a particular region, one must isolate the component of the observed concentration attributable to fluxes inside the region by removing the background, which is the component due to fluxes outside.

Greenhouse gas observations from the Northeast Corridor tower network.

We present the organization, structure, instrumentation, and measurements of the Northeast Corridor greenhouse gas observation network. This network of tower-based in situ carbon dioxide and methane observation stations was established in 2015 with the goal of quantifying emissions of these gases in urban areas in the northeastern United States. A specific focus of the network is the cities of Baltimore, MD, and Washington, DC, USA, with a high density of observation stations in these two urban areas.

Managing a Lateral Periodontal Cyst With Bone Graft: A Computed Tomography Assessment 18 Months Postoperatively.

The lateral periodontal cyst is a rare benign lesion that is generally asymptomatic and commonly discovered by routine intraoral radiography. Reports on proper management of this lesion are readily available. However, the literature is sparse regarding the long-term outcomes following surgery.

Development of stable lyophilized protein drug products.

Freeze drying, or lyophilization is widely used for biopharmaceuticals to improve the long term storage stability of labile molecules. This review examines general theory and practice of rational lyophilization of biopharmaceuticals. Formulation development involving the selection of appropriate excipients, their associated physical properties, and mechanism of action in achieving a stable drug product are primary considerations for a successful lyophilization program.

Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth.

Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-27632 could inhibit melanoma in vitro and in vivo. We demonstrate that Y-27632 treatment of a panel of melanoma cells alters cellular morphology leading to spindly cells with decreased lamellipodia and increased filopodia formation.

Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate.

Understanding the intermolecular products of antibodies as a consequence of host-cell expression, aging, and heat-stress can be insightful especially when it involves the development of a stable biopharmaceutical product. The dimerized form of Epratuzumab (an IgG(1) antibody) with a molecular mass of approximately 300 kDa (twice the monomer antibody molecular weight of approximately 150 kDa) was examined to gain a better perspective of its properties pertaining to structure and activity. The nascent dimer was shown to partially dissociate upon incubation at 30 degrees C and 37 degrees C, exhibit no discernable alteration of structure (i.

Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells.

The effect of natriuretic peptides on forskolin-evoked adenylyl cyclase activity was investigated in dispersed gill cells from the Australian short-finned eel (Anguilla australis). Molecular cloning techniques were employed to identify the putative G-protein-activating motif within the intracellular domain of the eel natriuretic peptide C receptor. Eel ANP, eel CNP and the NPR-C-specific C-ANF inhibited the forskolin-stimulated production of cyclic AMP.

Sodium chloride enhances the storage and conformational stability of BDNF and PEG-BDNF.

Purpose: BDNF, a noncovalent homodimer, was modified by covalently attaching polyethylene glycol (PEG) with an average molecular weight of 20kDa to the N-terminal methionine. Stability of modified BDNF (PEG-BDNF) in aqueous solution was compared to BDNF after storage at elevated temperature in the presence and absence of NaCl.

Methods: SDS-PAGE.

Assessing bilingual and monolingual Latino students with translations of the MMPI-2: initial data.

This article presents the results of 2 studies conducted with Spanish versions of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) with Latino students. Study 1 compared the results of 2 administrations of the MMPI-2, one in English and the other in Spanish. Study 2 compared the results of administrations of 2 Spanish versions of the MMPI-2, the official Mexican adaptation and the Version Hispana.

Evidence of a guanylyl cyclase natriuretic peptide receptor in the gills of the new zealand hagfish Eptatretus cirrhatus (Class Agnatha).

Natriuretic peptide binding sites were examined in the gills of the hagfish Eptatretus cirrhatus (Class Agnatha, subfamily Eptatretinae) using radio-ligand binding techniques, molecular cloning and guanylyl cyclase assays. Iodinated rat atrial natriuretic peptide ((125)I-rANP) and iodinated porcine C-type natriuretic peptide ((125)I-pCNP) bound specifically to the lamellar folds and cavernous tissue of E. cirrhatus gills, and 0.

The medicalization of menopause: implications for recruitment of study participants.

Objective: Early studies of menopause recruited sample populations from clinical settings; however, in the 1970s, populations drawn from health care settings were characterized as nonrepresentative because of symptom overreporting. This pilot study was carried out to test whether this characterization still holds true: that women who are drawn from clinical settings report more symptoms compared with women who are recruited from community and work sites.

Design: Open-ended interviews were carried out with patients aged 40-60 years in a physician's office (n = 50), in a chiropractor's office (n = 24), at two Breast Health Project sites (n = 50), and in several non-health care sites in the community (n = 81).

Suppression of tonic luteinizing hormone secretion and norepinephrine release near the GnRH neurons by estradiol in ovariectomized rats.

One of the major neurotransmitters that controls pulsatile luteinizing hormone (LH) secretion is norepinephrine (NE). NE pulses detected in the median eminence of ovariectomized rhesus monkeys are highly correlated with both GnRH and LH pulses. In contrast, previous reports suggest that this is not the case in rats, thus it remains to be determined whether NE stimulates LH release on a pulse-by-pulse basis in that species.

MMPI performance of central American refugees and Mexican immigrants.

This study compared the MMPI scores of Central American refugees from Guatemala and El Salvador to those of Mexican immigrants. It was expected that subjects from Guatemala and El Salvador would obtain higher scores on the F, D, Pa, and Sc scales because these subjects came from "war-torn" countries. A multivariate analysis of variance yielded no significant differences between the three groups on any of the validity and clinical scales including F, D, Pa, and Sc.

Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor.

The topical application of recombinant growth factors such as epidermal growth factor, platelet-derived growth factor-BB homodimer (rPDGF-BB), keratinocyte growth factor (rKGF), and neu differentiation factor has resulted in significant acceleration of healing in several animal models of wound repair. In this study, we established highly reproducible and quantifiable full and deep partial thickness porcine burn models in which burns were escharectomized 4 or 5 days postburn and covered with an occlusive dressing to replicate the standard treatment in human burn patients. We then applied these growth factors to assess their efficacy on several parameters of wound repair: extracellular matrix and granulation tissue production, percent reepithelialization, and new epithelial area.

DSM-III-R training in master's-level counseling programs.

The DSM-III--R is used by the subdisciplines of mental health including psychiatry, psychology, and social work. Yet, of all subdisciplines, it has historically met the most resistance from the counseling profession. Until the early 1980s, discussion of the DSM in the counseling literature was taboo.

Hispanic-white MMPI comparisons: does psychiatric diagnosis make a difference?

Recent research on Blacks or African-Americans in psychiatric settings suggests that Black-White MMPI differences are minimized or eliminated when researchers match or control for key moderator variables, including psychiatric diagnosis. This study attempted to determine whether Hispanic-White MMPI differences are either minimized or eliminated when Hispanics and Whites are matched on three key moderator variables--age, education, and psychiatric diagnosis. Results suggest that even after controlling for these variables, MMPI differences between Hispanics and Whites are evident.

Dominant negative MYC blocks transformation by ABL oncogenes.

A link between ABL oncogenes and MYC is suggested by the transformation synergy that is observed when MYC is expressed at high levels. Dominant negative MYC proteins were overexpressed in fibroblasts to determine if MYC complements ABL oncogene transformation or is essential for this process. Transformation by both v-abl and BCR-ABL oncogenes was reduced 5- to 10-fold, whereas transformation by the serine/threonine kinase oncogene v-mos was unaffected.

MMPI-ER two-point codes of industrially injured Hispanic workers by DSM-III--R diagnosis.

The purpose of this study was to describe the MMPI-ER two-point codes of 492 Hispanic adults who had sustained work-related injuries and who had applied for workers' compensation benefits. More specifically, the focus was on whether there are unique MMPI two-point codes for Hispanic workers with three specific types of DSM-III--R diagnoses--adjustment disorder, anxiety disorder, and major depression. Analysis suggests that psychiatric condition or diagnosis may act as a moderator variable in Hispanic persons' MMPI performance, including MMPI two-point codes.

MMPI differences among Mexican-American male and female psychiatric inpatients.

The purpose of this study was to examine to what extent Mexican-American male and female psychiatric patients, who share similar DSM-III--R diagnoses, differ on the MMPI. Differences were found on the Infrequency, Masculinity-Femininity, and Paranoia scales, with the 39 men obtaining significantly higher scores than the 21 women. These results, while suggesting possible differences in the phenomenology of depression, also suggest that MMPI differences between Mexican-American men and women may be reflective of culturally-defined sex roles.

MMPI comparisons of Hispanic- and white-American veterans seeking treatment for alcoholism.

Scores of 29 Hispanic- and 46 white-American alcoholics, who voluntarily sought psychiatric treatment for their alcoholism, were compared on the MMPI. It was hypothesized that Hispanic-American alcoholics would be better adjusted than white alcoholics on the validity and clinical scales of the MMPI. The hypothesis was supported, with Hispanic-Americans obtaining significantly lower scores than white veterans on the Pd, Mf, and Si scales.