Publications by authors named "Calista M Greenwood"
Article Synopsis
- Adeno-associated viral (AAV) vectors are effective for in vivo gene therapy but are challenged by the immune system, particularly CD8 T-cell responses against transgene products.*
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- The study found that blocking multiple innate immune pathways is necessary to reduce immune responses; however, simply blocking these pathways might not completely prevent immune activation, especially at higher vector doses.*
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- A strategy incorporating CpG depletion and TLR9 inhibitory sequences, along with muscle-specific promoters, showed promise in sustaining transgene expression with minimal immune activation, highlighting the complexity of immune responses in gene therapy.*
