Publications by authors named "Caliel D Hines"
Adv Drug Alcohol Res
April 2022
Article Synopsis
- Rising opioid use during pregnancy is increasing the number of neonates exposed to opioids prenatally, with unclear effects on brain development.
- A study using a mouse model for prenatal methadone exposure (PME) found long-lasting changes in the primary somatosensory cortex (S1), impacting sensory development and demonstrating significant sex-based differences in protein and synaptic function.
- Key findings included decreased GABAergic synapses, reduced inhibitory currents in neurons, and lowered microglia density in the S1, highlighting the lasting neurobiological consequences of prenatal opioid exposure, particularly in females.
