Publications by authors named "Caleb Leach"
Article Synopsis
- Research is focused on finding new biologically active compounds, specifically Azothioformamides (ATFs), which can form stable coordination complexes with metals like copper for potential anticancer and antimicrobial therapies.
- In this study, different ATF ligands with varying heterocyclic groups were synthesized and complexed with Cu(I) salts, which were chosen for their potential lower toxicity and effective binding properties.
- The results indicated that smaller pyrrolidine-substituted ATFs showed stronger binding to Cu(I) salts and had varying levels of antimicrobial activity, particularly against some cancer cell lines, while the ATF ligands alone showed limited effectiveness.
Redox-active azothioformamides (ATFs) contain an NNCS 1,3-heterodiene motif typically found in other molecular subclasses that exhibit a wide range of cytotoxic and anti-neoplastic effects, either alone or as chelation complexes with various metals. For this study, a small library of ATF compounds was synthesized and tested across a range of microbes, fungi, and cancer cell lines for biological activity, both alone and as metal chelates of copper(I) and silver(I) salts. Alone, the ATF compounds exhibited little antimicrobial activity, but all inhibited the cell growth of A549 lung carcinoma cells (IC values of 1-6 μM).
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