Publications by authors named "Caleb Hoover"
Epidural spinal cord stimulation (eSCS) of the lower thoracic spinal cord has been shown to partially restore volitional movement in patients with complete chronic spinal cord injury (cSCI). Combining eSCS with intensive locomotor training improves motor function, including standing and stepping, but many patients with cSCI suffer from long-standing muscle atrophy and loss of bone mineral density, which may prohibit safe implementation. Safe, accessible, and effective avenues for pairing neuromodulation with activity-based therapy remain unexplored.
View Article and Find Full Text PDFObjectives: Epidural spinal cord stimulation (eSCS) has shown promise for restoring some volitional motor control after spinal cord injury (SCI). Maximizing therapeutic response requires effective spatial stimulation generated through careful configuration of anodes and cathodes on the eSCS lead. By exploring the way the spatial distribution of low frequency stimulation affects muscle activation patterns, we investigated the spatial specificity of stimulation-evoked responses for targeted muscle groups for restoration after chronic SCI (cSCI) in participants in the Epidural Stimulation After Neurologic Damage (E-STAND) trial.
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- This study looked at how safe epidural spinal cord stimulation (eSCS) is for people with spinal cord injuries (SCI).
- The researchers followed 14 participants at medical centers in Minnesota and monitored their health after receiving eSCS.
- They found no major problems from the surgery or the device, and eSCS seemed just as safe for SCI patients as it is for treating chronic pain.
Optimization of Spinal Cord Stimulation Using Bayesian Preference Learning and Its Validation.
IEEE Trans Neural Syst Rehabil Eng
October 2021
Epidural spinal cord stimulation has been reported to partially restore volitional movement and autonomic functions after motor and sensory-complete spinal cord injury (SCI). Modern spinal cord stimulation platforms offer significant flexibility in spatial and temporal parameters of stimulation delivered. Heterogeneity in SCI and injury-related symptoms necessitate stimulation personalization to maximally restore functions.
View Article and Find Full Text PDFChronic spinal cord injury (SCI) portends a low probability of recovery, especially in the most severe subset of motor-complete injuries. Active spinal cord stimulation with or without intensive locomotor training has been reported to restore movement after traumatic SCI. Only three cases have been reported where participants developed restored volitional movement with active stimulation turned off after a period of chronic stimulation and only after intensive rehabilitation with locomotor training.
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- Traumatic brain injuries (TBIs) are often not diagnosed properly, leading to ongoing issues, and current methods rely heavily on physical exams and imaging.
- A study involved comparing blood samples for specific biomarkers (GFAP, UCH-L1, and S100B) from trauma patients and controls, focusing on their levels shortly after injury and later.
- GFAP was found to be the most effective biomarker for predicting CT-positive TBIs, showing better sensitivity and specificity compared to UCH-L1 and S100B, especially 12-32 hours after injury.