Publications by authors named "Caleb Green"
BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. We investigated the impact of short-term (3 days) and long-term (6 months) expression of Braf in the intestinal tissue of an inducible mouse model. We show that Braf perturbs the homeostasis of intestinal epithelial cells, with impaired differentiation of enterocytes emerging after prolonged expression of the oncogene.
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- Scientists are studying how proline, a non-essential amino acid, affects cancer growth.
- They discovered that a specific protein, PYCR1, is found in higher amounts in cancer cells and helps them grow and survive.
- Their research shows that blocking the process that makes proline could be a good way to create new treatments for cancer.