Publications by authors named "Caleb A Seekins"
Background: Terpenes from Cannabis show promise for pain management. Our lab found that the terpenes geraniol, linalool, β-caryophyllene, and α-humulene relieve chemotherapy-induced peripheral neuropathy via Adenosine A receptors (AR). This suggests terpenes as potential non-opioid, non-cannabinoid therapeutics.
View Article and Find Full Text PDFTerpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa . A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals. However, these studies were methodologically limited and few established mechanisms of action.
View Article and Find Full Text PDFArticle Synopsis
- * In a study, several terpenes were tested on mice with pain from chemotherapy and inflammation, showing that their pain-relief effects were comparable to standard painkillers like morphine, and they did not produce any rewarding effects typically associated with drugs.
- * Researchers identified the adenosine A receptor in the spinal cord as the main mechanism through which these terpenes provide pain relief, indicating potential for these compounds to be developed into treatments for chronic pain.