Evaluation of reversible cytochrome P450 inhibition by Withania somnifera leaf and root extracts.

It is important to understand the potential of botanical-drug interactions to ensure the safe use of botanical dietary supplements (BDS). Cytochrome P450 (P450) is one of the most abundant phase 1 drug-metabolizing enzymes and is accountable for a great deal of pharmacokinetic botanical-drug interactions. This problem is particularly acute for older adults who often consume BDS with multiple prescription medicines.

Preclinical evaluation of the RBD-Trimeric vaccine: A novel approach to strengthening biotechnological sovereignty in developing countries against SARS-CoV-2 variants.

Unlabelled: New immunogens against emerging new virus variants are essential for controlling new variants.

Methods: A preclinical study in which a receptor-binding domain (RBD) trimer was designed in silico with information from the Beta (B.1.

Search for New Resonances Decaying to Pairs of Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13 TeV.

A search is presented for an extended Higgs sector with two new particles, X and ϕ, in the process X→ϕϕ→(γγ)(γγ). Novel neural networks classify events with diphotons that are merged and determine the diphoton masses. The search uses LHC proton-proton collision data at sqrt[s]=13  TeV collected with the CMS detector, corresponding to an integrated luminosity of 138  fb^{-1}.

Exploring the Impact of Non-Ablative Erbium Laser Therapy on Recurrent Vaginal Candidiasis.

Objectives: To assess the effect of non-ablative Er:YAG laser therapy on the symptoms and microbiological conditions of women with recurrent vulvovaginal candidiasis (RVVC).

Materials And Methods: One hundred and sixty-seven women (mean age 34.1 ± 8.

Trends in psychological distress during and after the COVID-19 pandemic: Findings from a population-based Costa Rican cohort study.

Objectives: The COVID-19 pandemic has resulted in an increase of psychological distress. We hypothesized that the mental health of individuals has improved since the end of the pandemic.

Study Design: 1459 population-based participants of the RESPIRA cohort study (Costa Rica) METHODS: Psychological distress was measured at 6-month intervals using the Mental Health Inventory 5 (MHI-5) during the 2-year follow-up.

Opioid use disorder prevalence in 57 New York counties from 2017 to 2019: A Bayesian evidence synthesis.

Introduction: Prevalence estimates of opioid use disorder (OUD) at local levels are critical for public health planning and surveillance, yet largely unavailable across the US especially at the local county level.

Methods: We used a Bayesian evidence synthesis approach to estimate the prevalence of OUD for 57 counties across New York State for 2017-2019 and compare rates of OUD across counties as well as assess the extent of undiagnosed OUD. We developed a generative model to assess conditional probabilistic relations between different subgroups of the OUD population defined by diagnosis, treatment, and overdose fatality.

Implementation and Experimental Application of Industrial IoT Architecture Using Automation and IoT Hardware/Software.

The paradigms of Industry 4.0 and Industrial Internet of Things (IIoT) require functional architectures to deploy and organize hardware and software taking advantage of modern digital technologies in industrial systems. In this sense, a lot of the literature proposes and describes this type of architecture with a conceptual angle, without providing experimental validation or with scarce details about the involved equipment under real operation.

The impact of stigma and discrimination-based narratives in the health of migrants in Latin America and the Caribbean: a scoping review.

Stigma and discrimination-based narratives have been associated with adverse health outcomes. Migrants and refugees face multiple barriers to accessing healthcare, influenced by stigma and discrimination-based narratives against them. We conducted a scoping review of scientific and grey literature (n = 61) to discuss available evidence in Latin America and the Caribbean (LAC) concerning communication and narrative speeches related to international migration and its implications for population health, particularly when associated with stigma and discrimination against migrants and refugees.

Depression is Associated with Treatment Response Trajectories in Adults with Prolonged Grief Disorder: A Machine Learning Analysis.

Unlabelled: Although evidence-based treatments for Prolonged Grief Disorder (PGD) exist, pretreatment characteristics associated with differential improvement trajectories have not been identified. To identify clinical factors relevant to optimizing PGD treatment outcomes, we used unsupervised and supervised machine learning to study treatment effects from a double-blinded, placebo-controlled, randomized clinical trial. Participants were randomized into four treatment groups for 20 weeks: citalopram with grief-informed clinical management, citalopram with prolonged grief disorder therapy (PGDT), pill placebo with PGDT, or pill placebo with clinical management.

Recently Delisted Songbird Harbors Extensive Genomic Evidence of Inbreeding, Potentially Complicating Future Recovery.

The Kirtland's warbler () is a rare migratory passerine species and habitat specialist of the North American Jack Pine Forests. Their near extinction in the 1970s classified them as endangered and protected under the Endangered Species Act of 1973. After decades of intense conservation management, their population size recovered, and they were delisted from federal protection in 2019.

Rodent group borreliae do occur in wild rodents from the Caribbean region of Colombia.

Background: Bacteria of the genus Borrelia are agents of disease in both domestic animals and humans and pose a significant public health risk. Borrelia species have complex transmission cycles, often using rodents as vertebrate reservoir hosts. These bacteria are classified into three well-defined monophyletic groups: Borrelia burgdorferi sensu lato (Bbsl) complex, the relapsing fever (RF) group, and a third group associated with reptiles and echidnas.

Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV.

The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

Data cleaning and harmonization of clinical trial data: Medication-assisted treatment for opioid use disorder.

Several large-scale, pragmatic clinical trials on opioid use disorder (OUD) have been completed in the National Drug Abuse Treatment Clinical Trials Network (CTN). However, the resulting data have not been harmonized between the studies to compare the patient characteristics. This paper provides lessons learned from a large-scale harmonization process that are critical for all biomedical researchers collecting new data and those tasked with combining datasets.

Health and University Students: The Mediator Role of Emotion Regulation Between Academic Stressors and Health Behaviors.

Purpose: To determine the role of Health Behaviors and Cognitive Emotion Regulation Strategies in the relationship between Health and Academic Stress.

Design: A cross-sectional study with in-person administration of questionnaires.

Setting: Data collection took place at nine public and private universities in Peru, involving a diverse group of students from different faculties.

Impact of knowledge of HPV positivity on cervical cytology performance in latin america.

Background: Cervical cytology is recommended by WHO as a triage option in HPV-based cervical cancer screening programmes. We assessed the performance of cytology to detect CIN3+ without and with knowledge of HPV positivity.

Methods: Women were screened with cytology and HPV across ESTAMPA study centres in Latin America.

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

Diffusion and thermodynamic properties of lithium polysulfides in different solvents: a molecular dynamics approach.

Li-S batteries are promising alternatives due to their proven increased gravimetric capacity compared to Li-ion batteries. However, their development is hindered by many technical issues, one of the most challenging being the dissolution and shuttle of polysulfide species, which causes irreversible loss of cathode material leading to rapid capacity fading. Among the possible strategies to mitigate this effect, the choice of suitable solvents is easy to implement and has large room for improvement.

Spatial proteomics of with pleomorphic neoplasms shows local and systemic dysregulation of protein expression.

is the agent of onchocerciasis (river blindness) and targeted by WHO for elimination though mass drug administration with ivermectin. A small percentage of adult worms develop pleomorphic neoplasms (PN) that are positively associated with the frequency of ivermectin treatment. Worms with PN have a lower life expectancy and a better understanding about the proteins expressed in PN, and how PN affect protein expression in different tissues could help to elucidate the mechanisms of macrofilaricidal activity of ivermectin.

Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals.

Botanical supplements, herbal remedies, and plant-derived products are used globally. However, botanical dietary supplements are rarely subjected to robust safety testing unless there are adverse reports in post-market surveillance. Botanicals are complex and difficult to assess using current frameworks designed for single constituent substances (e.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

A U.S. Pharmacopeia (USP) overview of Pan American botanicals used in dietary supplements and herbal medicines.

The United States Pharmacopeial Convention (USP) is a nonprofit, scientific, standard-setting organization, and world leader in establishing quality, purity, and testing standards for medicines, foods, and dietary supplements. USP quality standards are used in more than 140 countries and are legally recognized by more than 40 countries. Currently, there is renewed interest in herbal medicines globally, and health policies are being implemented worldwide for the use of complementary and traditional medicine.