An overview of outcome measures used in neuropsychological rehabilitation research on adults with acquired brain injury.

Outcome measurement is the cornerstone of evidence-based health care including neuropsychological rehabilitation. A complicating factor for outcome measurement in neuropsychological rehabilitation is the enormous number of measures available and the lack of a standard set of outcome measures. As a first step towards such a set, we reviewed intervention evaluation studies of the last 20 years to get an overview of instruments used for measuring outcome.

Role of acetylcholine and serotonin in novelty processing using an oddball paradigm.

The processing of novel stimuli is known to take place in the hippocampus and frontal cortex, and is influenced by the cholinergic system. This ability is crucial to help detect changes in the environment and adapt behaviour accordingly. Previous research has shown that acetylcholine (ACh) can interact with serotonin (5-HT) at the hippocampal level, which may have consequences for cognitive functioning.