Generalizing Monin-Obukhov Similarity Theory (1954) for Complex Atmospheric Turbulence.

Monin-Obukhov similarity theory (MOST) forms the basis for parametrizations of turbulent exchange in virtually all numerical models of atmospheric flows. Yet, its limitations to flat and horizontally homogeneous terrain have plagued the theory since its inception. Here we present a first generalized extension of MOST based on the inclusion of turbulence anisotropy as an additional nondimensional term.

Incorporating the effect of heterogeneous surface heating into a semi-empirical model of the surface energy balance closure.

It was discovered several decades ago that eddy covariance measurements systematically underestimate sensible and latent heat fluxes, creating an imbalance in the surface energy budget. Since then, many studies have addressed this problem and proposed a variety of solutions to the problem, including improvements to instruments and correction methods applied during data postprocessing. However, none of these measures have led to the complete closure of the energy balance gap.

Anisotropy of Unstably Stratified Near-Surface Turbulence.

Classic Monin-Obukov similarity scaling states that in a stationary, horizontally homogeneous flow, in the absence of subsidence, turbulence is dictated by the balance between shear production and buoyancy production/destruction, whose ratio is characterized by a single universal scaling parameter. An evident breakdown in scaling is observed though, through large scatter in traditional scaling relations for the horizontal velocity variances under unstable stratification, or more generally in complex flow conditions. This breakdown suggests the existence of processes other than local shear and buoyancy that modulate near-surface turbulence.

Translation, cultural adaptation, and psychometric properties of the Spanish version of the Combat Exposure Scale (CES-S) with U.S. military Spanish speaking Latino veterans living in the Caribbean: A cross-sectional preliminary data study.

Objective: The Combat Exposure Scale (CES) is one of the most used self-report instruments to assess various combat situations experienced by military personnel. This article presents a comprehensive translation and cultural adaptation of the CES to Spanish and its psychometric properties.

Method: Fifty-five (n = 55) U.

Universal Return to Isotropy of Inhomogeneous Atmospheric Boundary Layer Turbulence.

A recalcitrant problem in the physics of turbulence is the representation of the tendency of large-scale anisotropic eddies to redistribute their energy content with decreasing scales, a phenomenon referred to as return to isotropy. An unprecedented dataset of atmospheric turbulence measurements covering flat to mountainous terrain, stratification spanning convective to very stable conditions, surface roughness ranging over several orders of magnitude, and Reynolds numbers that far exceed the limits of direct numerical simulations and laboratory experiments was assembled for the first time and used to explore the scalewise return to isotropy. The multiple routes to energy equipartitioning among velocity components are shown to be universal once the initial anisotropy at large scales, linked to turbulence generation, is accounted for.

Extramedullary multiple myeloma patient-derived orthotopic xenograft with a highly altered genome: combined molecular and therapeutic studies.

Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established. Besides, well-characterized preclinical models for EMM are not available.

Utility-scale solar PV performance enhancements through system-level modifications.

Performance of solar PV diminishes with the increase in temperature of the solar modules. Therefore, to further facilitate the reduction in cost of photovoltaic energy, new approaches to limit module temperature increase in natural ambient conditions should be explored. Thus far only approaches based at the individual panel level have been investigated, while the more complex, systems approach remains unexplored.

Solar PV Power Potential is Greatest Over Croplands.

Solar energy has the potential to offset a significant fraction of non-renewable electricity demands globally, yet it may occupy extensive areas when deployed at this level. There is growing concern that large renewable energy installations will displace other land uses. Where should future solar power installations be placed to achieve the highest energy production and best use the limited land resource? The premise of this work is that the solar panel efficiency is a function of the location's microclimate within which it is immersed.

Dependence of near-surface similarity scaling on the anisotropy of atmospheric turbulence.

Turbulence data from the CASES-99 field experiment, over comparatively horizontally homogeneous and flat terrain, are separated based on the anisotropy of the Reynolds stress tensor (into isotropic, two-component axisymmetric and one-component turbulence) and flux-variance similarity scaling relations are tested. Results illustrate that different states of anisotropy correspond to different similarity relations, especially under unstable stratification. Experimental data with close to isotropic turbulence match similarity relationships well.

Scaling, Anisotropy, and Complexity in Near-Surface Atmospheric Turbulence.

The development of a unified similarity scaling has so far failed over complex surfaces, as scaling studies show large deviations from the empirical formulations developed over flat and horizontally homogeneous terrain as well as large deviations between the different complex terrain data sets. However, a recent study of turbulence anisotropy for flat and horizontally homogeneous terrain has shown that separating the data according to the limiting states of anisotropy (isotropic, two-component axisymmetric and one-component turbulence) improves near-surface scaling. In this paper we explore whether this finding can be extended to turbulence over inclined and horizontally heterogeneous surfaces by examining near-surface scaling for 12 different data sets obtained over terrain ranging from flat to mountainous.

Pathways for mitigating thermal losses in solar photovoltaics.

To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the thermal losses.

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RNA editing, are worth exploring. Herein we show that the adenosine-to-inosine editing enzyme ADAR1 undergoes gene amplification in non-small cancer cell lines and primary tumors in association with higher levels of the corresponding mRNA and protein.

Trace metal partitioning in caustic calcined magnesia produced from natural magnesite.

Caustic calcined magnesia from natural magnesite has been widely employed as a source of magnesium. This mineral, depending on the origin, may contain heavy metals and metalloids that can exceed the regulatory limits in some applications. In most cases, heavy metals and metalloids form solid solutions with the mineral phases of the main impurities, or even magnesium oxide itself, replacing other ions in the crystal lattice.

Assessing the RNA effect of 26 DNA variants in the BRCA1 and BRCA2 genes.

Comprehensive genetic testing of the breast cancer susceptibility genes BRCA1 and BRCA2 identified approximately 16% of variants of unknown significance (VUS), a significant proportion of which could affect the correct splicing of the genes. Our aim is to establish a workflow for classifying VUS in these complex genes, the first stage of which is splicing analysis. We used a combined approach consisting of five in silico splicing prediction programs and RT-PCR analysis for a set of 26 variants not previously studied at the mRNA level and six variants that had already been studied, four of which were used as positive controls as they were found to affect the splicing of these genes and the other two were used as negative controls.

Are there gender-specific pathways from early adolescence psychological distress symptoms toward the development of substance use and abnormal eating behavior?

The aim of the present longitudinal community study was to test whether psychological distress at 13 years of age predicted reported substance use problems in boys and abnormal eating behavior in girls 2 years later. The sample consisted of 500 male and 576 female students. The use of substances was evaluated using a semi-structured interview, psychological distress with the General Health Questionnaire (GHQ) and eating psychopathology with the Eating Attitudes Test (EAT-40), and the Bulimic Investigatory Test Edinburgh (BITE).

Comorbidity between obesity and attention deficit/hyperactivity disorder: population study with 13-15-year-olds.

Objective: This study analyzes whether obese children have a higher risk of attention deficit/hyperactivity "characteristics" (AD/HD) than do children with other nutritional states.

Method: This study included 35,403 participants from 486 community schools. They completed the AD/HD scale of the Strengths and Difficulties Questionnaire (SDQ) and were weighed and measured.

Evaluation of RLBP1 in 50 autosomal recessive retinitis pigmentosa and 4 retinitis punctata albescens Spanish families.

Defects in retinal vitamin A metabolism or in genes expressed in the retinal pigment epithelium (RPE) are related to nonsyndromic retinitis pigmentosa (RP). The RLBP1 gene encodes the cellular retinaldehyde-binding protein which, in the RPE and Müller cells of the retina, is thought to play a role in retinoid metabolism and visual pigment regeneration. We describe a study of the involvement of the RLBP1 gene in 50 autosomal recessive retinitis pigmentosa (ARRP) and four retinitis punctata albescens Spanish families.

Analysis of the IRBP gene as a cause of RP in 45 ARRP Spanish families. Autosomal recessive retinitis pigmentosa. Interstitial retinol binding protein. Spanish Multicentric and Multidisciplinary Group for Research into Retinitis Pigmentosa.

Autosomal recessive retinitis pigmentosa (ARRP) is a degenerative disorder of photoreceptors. Mutations in several genes encoding different proteins of the visual cascade are described. The inheritance of two intragenic markers within the interstitial retinol binding protein (IRBP) gene was established in 45 Spanish families with a history of ARRP.

[Identification of 2 allelic mutations of the gene of the phosphodiesterase beta subunit in a Spanish family with recessive autosomic retinitis pigmentosa].

Background: Retinitis pigmentosa (RP) is a group of inherited eye disorders that affect photoreceptor and pigment epithelial function. Mutations in different genes involved in the phototransduction process have been described in patients with autosomal recessive RP.

Patients And Methods: We examined the gene coding the beta subunit of the phosphodiesterase (PDEB) in a ARRP family with two affected sisters.