Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration.

This study aimed to address the roles of long non-coding RNA (lncRNA) MIR155HG in melanoma cell proliferation and apoptosis, as well as the roles of deregulated MIR155HG in melanoma cells in regulation M1/M2 macrophage balance and macrophage infiltration. In this study, melanoma A375 and SK-MEL-28 cells that transfected with MIR155HG knockdown or overexpression plasmid were subjected to examinations of cell viability, colony formation ability, cell cycle distribution and apoptosis. Then, monocytic THP-1 cells were differentiated and polarized into M1 and M2 phenotypes.