Long-term exposure to particulate matter pollution and incidence of ischemic and hemorrhagic stroke: A prospective cohort study in Eastern China.

Although epidemiological studies have demonstrated significant associations of long-term exposure to particulate matter (PM) air pollution with stroke, evidence on the long-term effects of PM exposure on cause-specific stroke incidence is scarce and inconsistent. We incorporated 33,282 and 33,868 individuals aged 35-75 years without a history of ischemic or hemorrhagic stroke at the baseline in 2014, who were followed up till 2021. Residential exposures to particulate matter with an aerodynamic diameter less than 2.

Incidence of thromboembolic events in non-small cell lung cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis.

The incidence of thromboembolic events (TEs) in non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs) has rarely been reported. The MEDLINE, EMBASE, and the Cochrane Library databases were searched. The primary outcome was the incidence of TEs, and the secondary outcome was the relationship between TEs and overall survival (OS) following ICI therapy.

Preventive effect of aspirin on peripherally inserted central catheter-related vein thrombosis in patients with malignant tumors.

Unlabelled: The majority of patients receiving chemotherapy undergo PICC catheterization. However, PICCs are significantly associated with catheter related complications, including deep vein thrombosis, blood infection, fibrin sheath, catheter prolapse, catheter displacement and blockage. Of all the risks, PICC-related VT was the most prevailing clinic symptom and resulted in a high risk of death.

Serum Protein-Based Profiles for the Diagnostic Model of Alzheimer's Disease.

Background: Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease.

Methods: We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM.

Synergetic Sn Incorporation-Zn Substitution in Copper-Based Sulfides Enabling Superior Na-Ion Storage.

Transition-metal sulfides have been regarded as perspective anode candidates for high-energy Na-ion batteries. Their application, however, is precluded severely by either low charge storage or huge volumetric change along with sluggish reaction kinetics. Herein, an effective synergetic Sn incorporation-Zn substitution strategy is proposed based on copper-based sulfides.

A blood-based, metabolite and demographic characteristic markers panel for the diagnosis of Alzheimer's disease.

This work was designed to provide early diagnosis strategies for Alzheimer's disease (AD) based on the identification of blood metabolic biomarkers. A total of 90 subjects aged 60 years or older were included in this study; 45 patients were assigned to the case group and control group, respectively. A total of 31 target metabolites were quantitatively analyzed by parallel reaction monitoring between the two groups.

A bibliometric study on the utilization of lenvatinib in hepatocellular carcinoma (2014-2022).

The REFLECT phase-III trial has demonstrated the efficacy of lenvatinib in improving the overall survival of advanced hepatocellular carcinoma (HCC) patients, comparable to sorafenib. The rapidly evolving landscape of hepatocellular carcinoma therapy presents new avenues for lenvatinib. This study aims to provide a scientometric analysis of publications and predict research hotspots in this field.

Long-term cardiometabolic effects of ambient ozone pollution in a large Chinese population.

Limited studies investigated the effects of long-term ozone exposure on cardiometabolic health. We aimed to examine the association of long-term ozone exposure with a range of cardiometabolic diseases, as well as the subclinical indicators in Eastern China. The study included 202,042 adults living in 11 prefecture-level areas in Zhejiang Province between 2014 and 2021.

Cohort study of the effects of occupation and environmental tobacco smoke on the incidence of Alzheimer's disease among seniors.

Introduction: Alzheimer's disease (AD) is a disease caused by many factors including occupational and environmental factors. Secondhand smoke (SHS) can affect cognitive function. However, there is limited recent epidemiological research on how SHS and occupational factors affect AD in Zhejiang province.

Associations between PM exposure and Alzheimer's Disease prevalence Among elderly in eastern China.

Background: Studies showed that PM might be associated with various neurogenic diseases such as Alzheimer's Disease (AD). However, this topic had been little studied in Zhejiang province of China.  METHODS: In 2018, we established a cohort of AD high-risk population with 1,742 elderly aged 60 and above.

Diagnostic Model of Alzheimer's Disease in the Elderly Based on Protein and Metabolic Biomarkers.

Background: With the accelerating aging process, the number of participants with Alzheimer's disease (AD) is rising sharply, causing a huge economic burden.

Objective: This study aimed to identify blood protein and metabolic biomarkers and explore the diagnostic model for AD among elderly in southeast China.

Methods: We established a cohort among population with high risk AD in Zhejiang Province in 2018.

Quasi-solid electrolyte developed on hierarchical rambutan-like γ-AlOOH microspheres with high ionic conductivity for lithium ion batteries.

Upgrading liquid electrolytes with all-solid-state electrolytes (ASEs) or quasi-solid-state electrolytes (QSEs) for solid-state batteries (SBs) have emerged not only to address the intrinsic disadvantages of traditional liquid lithium ion batteries, but also to offer more possibilities for the development of new battery chemistries. In this work, a novel rambutan-like yolk-shell-structured porous γ-AlOOH microsphere with a large specific surface area of 262.92 m g was firstly obtained by a simple hydrothermal synthesis route, which was then utilized as a robust framework to assemble QSE via encapsulating abundant liquid electrolyte (LE).

A Novel Salen-based Porous Framework Polymer as Durable Anode for Lithium-Ion Storage.

Organic electrode materials with abundant resources, environmental friendliness and recyclability play a crucial role in rechargeable lithium-ion batteries (LIBs). However, the inferior electrical conductivity and unsatisfactory long-term cycling performance seriously impede their large-scale application in LIBs. Herein, a novel salen-based porous framework polymer (SPP) with a large conjugated skeleton was constructed and utilized as anode for LIBs.

Efficacy and safety of regorafenib or fruquintinib plus camrelizumab in patients with microsatellite stable and/or proficient mismatch repair metastatic colorectal cancer: an observational pilot study.

This study was to investigate the efficacy and safety of regorafenib or fruquintinib combined with camrelizumab in patients with microsatellite stable (MSS) and/or proficient mismatch repair (pMMR) metastatic colorectal cancer (mCRC). Medical records of MSS/pMMR mCRC patients who received regorafenib (80 mg) or fruquintinib (3 mg) once a day (21 days on/7 days off) plus camrelizumab (200 mg) every three weeks in Yuhuangding Hospital between January 2020 and June 2020 were retrospectively collected. Follow-up data up to November 1st, 2020 was gathered.

Effects of comprehensive intervention on life quality among the elderly with Alzheimer Disease and their caregivers based on mixed models.

Aims: We conducted a multi-sectoral comprehensive intervention for elderly Alzheimer Disease patients and their caregivers to improve their quality of life.

Design: Randomized controlled trial.

Methods: From June to June in 2019, 150 Alzheimer Disease patients were randomly selected from a nursing home in Zhejiang province of China, they were randomly divided into the intervention group and the control group.

Local Electric-Field-Driven Fast Li Diffusion Kinetics at the Piezoelectric LiTaO Modified Li-Rich Cathode-Electrolyte Interphase.

As one of the most promising cathodes for next-generation lithium ion batteries (LIBs), Li-rich materials have been extensively investigated for their high energy densities. However, the practical application of Li-rich cathodes is extremely retarded by the sluggish electrode-electrolyte interface kinetics and structure instability. In this context, piezoelectric LiTaO is employed to functionalize the surface of LiNiMnCoO (LNMCO), aiming to boost the interfacial Li transport process in LIBs.

Stabilizing a high-voltage LiNiMnO cathode towards all solid state batteries: a Li-Al-Ti-P-O solid electrolyte nano-shell with a host material.

LiNi0.5Mn1.5O4 (LNMO) spinel has drawn increasing attention due to its high voltage, stabilized electrochemical performance and safety features as a cathode for lithium-ion batteries.

Controllable and facile synthesis of CsPbBr-CsPbBr perovskite composites in pure polar solvent.

Here, we present a single atomic supersaturated recrystallization method to synthesize the green-emitting CsPbBr-CsPbBr perovskite composites in solid state with the highest PLQY of 40.8% in pure polar solvent. The component, morphology, and optical properties of the microcrystals can be tuned by varying growth time, the content of ammonium bromide, and bromine source.

Synthesis of Eu/Eu Co-Doped Gallium oxide nanocrystals as a full colour converter for white light emitting diodes.

Eu and Eu co-doped GaO nanocrystals (GaO:Eu NCs) were synthesized in an organic phase at a low reaction temperature of 300 °C. The surface of GaO:Eu NCs was passivated by oleylamine (OAm) and acetylacetone (acac). The coexistence of Eu and Eu as well as passivation by acac and OAm enable GaO to be excited in the broad spectral range of 200-500 nm.

Knockdown of LINC01614 inhibits lung adenocarcinoma cell progression by up-regulating miR-217 and down-regulating FOXP1.

We tried to identify the function of LINC01614 in lung adenocarcinoma (LUAD) and reveal its underlying mechanisms. qRT-PCR was applied to assess the expression of LINC016014 in LUAD tissues, noncancerous tissues and cells. Through colony formation assay, MTT assay and apoptosis analysis, we examined the variation of cell proliferation and apoptosis ability after silencing LINC01614.

Efficacy and Safety of Nab-Paclitaxel as Second-line Chemotherapy for Locally Advanced and Metastatic Non-small Cell Lung Cancer.

Aim: To investigate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for locally advanced or metastatic non-small cell lung cancer (NSCLC) as second-line chemotherapy.

Patients And Methods: We retrospectively reviewed the treatment of 34 patients with advanced NSCLC whose first-line treatment had failed. These patients received nab-paclitaxel 260 mg/m on day 1 and day 8 of a 21-day cycle from July 2014 to February 2016.

Facile Synthesis of Cadmium-Free Zn-In-S:Ag/ZnS Nanocrystals for Bio-Imaging.

High quality cadmium-free Zn-In-S:Ag doped-nanocrystals (d-NCs) were synthesized via a simple one-step noninjection route using silver nitrate, indium acetate, zinc acetate, oleylamine, S powder and 1-dodecanethiol as starting materials in an organic phase. The size and optical properties can be effectively tailored by controlling the reaction time, reaction temperature, Ag(+) dopant concentration, and the molar ratio of In to Zn. The photoluminescence wavelength of as-prepared Zn-In-S:Ag NCs covered a broad visible range from 458 nm to 603 nm.

Sn-doped TiO2 nanotubes as superior anode materials for sodium ion batteries.

Sn-doped TiO2 nanotubes were employed as anodes for sodium ion batteries. The electrodes exhibit a high maximum charge capacity of 257 mA h g(-1) after 50 cycles at a current density of 50 mA g(-1) with good rate capability and especially excellent cycling stability, mainly due to the increase of electrical conductivity by Sn doping.

Analysis of the differences of serum protein mass spectrometry in patients with triple negative breast cancer and non-triple negative breast cancer.

The objective of the present study was to investigate differences of serum protein mass spectrometry in patients with triple negative breast cancer (TNBC) and non-TNBC and thus to search for candidate serum protein biomarkers for identification and diagnosis of TNBC. Thirty serum samples from patients with TNBC without any treatment and 30 serum samples from patients with non-TNBC without any treatment were detected by using two-dimensional gel electrophoresis and matrix-assisted laser dissociation tandem time-of-flight mass spectrometry (MALDI-TOF-MS). PDQest 7.

Clinicopathologic characteristics and prognostic factors in patients with operable HER-2 overexpressing breast cancer.

Objective: To study the relationship between clinical pathologic characteristics, treatment modalities and prognostic factors in HER-2 (Human Epidermal growth factor Receptor-2) overexpressed breast carcinoma.

Materials And Methods: Major clinico-pathological factors including therapeutic modalities and survival status of 371 breast cancer patients with HER2 over-expression, teated at Yantai Yuhuangding Hospital from March of 2002 to December of 2010 were retrospectively studied, with special attention focused on survival-related factors.

Results: The median age of the total 371 patients in this study was 48 years at time of diagnosis, among which, the leading pathological type was infiltrating ductal carcinoma (92.