Genomics Proteomics Bioinformatics
February 2025
The Genome Warehouse (GWH), accessible at https://ngdc.cncb.ac.
View Article and Find Full Text PDFIn this work, an anionic framework Co-MOF () was elaborately constructed, which underwent single-crystal-to-single-crystal (SC-SC) transformation to produce and after immersion in a CrCl or FeCl solution. Despite the similar crystal structure, the significantly enhanced proton conductivities of and far exceed that of at all humidity and temperature conditions. Even at 30 °C and 98% RH, the proton conductivity of and can reach up to high values of 1.
View Article and Find Full Text PDFFront Neurorobot
December 2024
Introduction: Segmentation tasks in computer vision play a crucial role in various applications, ranging from object detection to medical imaging and cultural heritage preservation. Traditional approaches, including convolutional neural networks (CNNs) and standard transformer-based models, have achieved significant success; however, they often face challenges in capturing fine-grained details and maintaining efficiency across diverse datasets. These methods struggle with balancing precision and computational efficiency, especially when dealing with complex patterns and high-resolution images.
View Article and Find Full Text PDFThe efficient and complete extraction of uranium from aqueous solutions is crucial for safeguarding human health from potential radiotoxicity and chemotoxicity. Herein, an ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately constructed, based on a calix[4]arene ligand. The large molecular skeleton and cup-shaped feature of the calix[4]arene enabled the as-prepared MOFs with large layer separations, which can be readily delaminated into ultrathin single-layer (∼1.
View Article and Find Full Text PDFThe efficient removal of radioactive uranium from aqueous solution is of great significance for the safe and sustainable development of nuclear power. An ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately fabricated based on a calix[4]arene ligand. Incorporating the permanent cavity structures on MOF nanosheet can fully utilize its structural characteristics of largely exposed surface area and accessible adsorption sites in pollutant removal, achieving ultrafast adsorption kinetics, and the functionalized cavity structure would endow the MOF nanosheets with the ability to achieve preconcentration and extraction of uranium from aqueous solution, affording ultrahigh removal efficiency even in ultra-low concentrations.
View Article and Find Full Text PDFAquaporin 3(AQP3) is involved in epithelial-mesenchymal transformation of tumor cells and is closely related to the occurrence and development of tumors. However, the regulatory mechanism and function of AQP3 in EBV-associated gastric cancer (EBVaGC) are still poorly understood. This study aims to explore the regulatory effect of EBV on AQP3 and the cross talk of AQP3 with EIF4E-binding proteins 1(4E-BP1) in EBVaGC.
View Article and Find Full Text PDFRadioactive iodine (I and I), produced or released from nuclear-related activities, posed severe effects on both human health and environment. The efficient removal of radioiodine from aqueous medium and vapor phase is of paramount importance for the sustainable development of nuclear energy. Herein, a metal-organic framework (MOF) nanosheet with a positive charge was constructed for the capture of iodine for the first time.
View Article and Find Full Text PDFLead (Pb) is one of the most widespread and highly toxic heavy metals in the environment. The design and synthesis of adsorbent materials for the selective and efficient removal of Pb from aqueous solution has received much attention. Herein, the ligand 4,4'-azoxydibenzoic acid with the O group was elaborately selected to construct a novel Pr-based MOF for Pb removal.
View Article and Find Full Text PDFTwo-dimensional (2D) metal-organic framework (MOF) nanosheets, with largely exposed surface area and highly accessible active sites, have emerged as a novel kind of sensing material. Here, a luminescent 2D MOF nanosheet was designed and synthesized by a facile top-down strategy based on a three-dimensional (3D) layered MOF {[Zn(HL)(HO)]·HO} (; HL = 3,5-bis(3',5'-dicarboxyphenyl)-1H-1,2,4-triazole). With a large π-conjugated system and rigid planar structure, ligand HL was elaborately selected to construct the bulk , which can be readily exfoliated into 2D nanosheets, owing to the weak interlayer interactions and easy-to-release HO molecules in the interspaces of 2D layers.
View Article and Find Full Text PDFBMC Public Health
December 2021
Background: Preventive risk factors such as smoking, drinking, and unhealthy weight have contributed to the accelerated rise in noncommunicable chronic diseases, which are dominant drivers of health care utilization and spending in China. However, few studies have been conducted using a large longitudinal dataset to explore the impact of such preventive risk factors on health care utilization. Therefore, this study aimed to ascertain the effects of smoking, regular drinking, and unhealthy weight on health care utilization in China.
View Article and Find Full Text PDFThe Genome Sequence Archive for Human (GSA-Human) is a data repository specialized for human genetic related data derived from biomedical researches, and also supports the data collection and management of National Key Research and Development Projects. GSA-Human has a data security management strategy according to the national regulations of human genetic resources. It provides two different models of data access: Open-access and Controlled-access.
View Article and Find Full Text PDFGenomics Proteomics Bioinformatics
August 2021
The Genome Sequence Archive (GSA) is a data repository for archiving raw sequence data, which provides data storage and sharing services for worldwide scientific communities. Considering explosive data growth with diverse data types, here we present the GSA family by expanding into a set of resources for raw data archive with different purposes, namely, GSA (https://ngdc.cncb.
View Article and Find Full Text PDFPCB 180 is a typical non-dioxin-like polychlorinated biphenyl (NDL-PCB). It is one of the most prevalent PCB-congeners found in human adipose tissue. However, the role of PCB 180 in obesity remains poorly understood.
View Article and Find Full Text PDFIncreasing evidence shows that Epstein-Barr virus (EBV) infection is closely related to various lymphoid and epithelioid malignancies. However, the underlying mechanisms are unclear. GCNT3 (core 2β-1,6-acetylglucosaminyltransferase) is a new type of core mucin synthase, and its expression in EBV-associated gastric cancer (EBVaGC) is lower than that in EBV-negative gastric cancer (EBVnGC).
View Article and Find Full Text PDFHexabromocyclododecane (HBCD) is a widely used brominated flame retardant, and a ubiquitous environmental contaminant. However, effects and mechanisms underlying HBCD and the development of obesity remain largely unknown. Here, we investigated the effects and underlying mechanisms of HBCD on adipogenesis.
View Article and Find Full Text PDFChem Commun (Camb)
November 2019
Single-crystal-to-single-crystal (SC-SC) structural self-evolution has been successfully performed on an amino-functionalized MOF material, which has greatly improved the Hg removal performance of the material and implemented dye molecule encapsulation through a dissolution-encapsulation-recrystallization process for the first time.
View Article and Find Full Text PDFJ Environ Sci (China)
November 2019
Methyl tert-butyl ether (MTBE), as a widely used gasoline additive, is suspected of being environmentally toxic. MTBE accumulates mainly in adipose tissue, but its effect on obesity or obesity-related metabolic disorders has not been well understood yet. Therefore, we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.
View Article and Find Full Text PDFClin Appl Thromb Hemost
November 2018
The use of tranexamic acid (TXA) for reducing blood loss in intertrochanteric fracture (IF) surgery remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of TXA in reducing transfusion requirements and blood loss for IF surgery. Databases, including PubMED, Cochrane, and Embase, were searched for RCTs that were published before February 2018 and that addressed the efficacy and safety of TXA in patients who underwent IF surgery.
View Article and Find Full Text PDFHeavy metal ions are highly toxic and widely spread as environmental pollutants. New strategies are being developed to efficiently remove these toxic ions. Herein, we use the intrinsic advantages of metal-organic frameworks (MOFs) and develop a porous Zn(ii)-based MOF decorated with O groups for the removal of Pb.
View Article and Find Full Text PDFwnt/β-catenin signaling has been shown to influence bone homeostasis and is important for parathyroid hormone (PTH)-induced bone gain. To further understand the role of β-catenin in the early stages of osteoblastic lineage cells for postnatal bone homeostasis and the anabolic actions of PTH on bone, we examined mice with postnatal disruption of β-catenin in osterix-expressing cells (β-catenin KO mice) by mating floxed β-catenin mice with transgenic mice expressing cre under the control of the osterix promoter suppressible by doxycycline. After withdrawal of doxycycline, β-catenin KO mice developed progressive bone loss, ectopic cartilage formation, accumulation of mesenchymal stromal cells, and bone marrow adiposity.
View Article and Find Full Text PDFIn this study, a novel coordination polymer [CdL₂(H₂O)] (), [HL = 4-(2-(4-((pyridin-3-yl)methoxy)phenyl)diazenyl)benzoic acid] was fabricated via an in situ ligand transformation reaction under solvothermal conditions. The as-prepared polymer exhibited a selectivity and efficiency for Cr(III) removal with a high uptake capacity of 106.13 mg·g.
View Article and Find Full Text PDFObesity, diabetes and osteoporosis have become a major public heath burden, and understanding the underlying mechanisms of these pathophysiological process will benefit their treatment. Osteoblast lineage cells in charge of the bone formation have been showed to participate in the whole-body energy metabolism. In this study, we identify that wnt/β-catenin signaling in osteoblasts could regulate global energy metabolism, including glucose homeostasis, fat accumulation and energy expenditure.
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