Publications by authors named "Caitriona Buckley"
Article Synopsis
- The study investigates mortality differences between critically ill patients with severe alcohol-associated hepatitis (sAH) and those with acute-on-chronic liver failure (ACLF) not caused by sAH, focusing on implications for prognosis and liver transplantation timing.
- A total of 463 ACLF patients were analyzed, revealing that those with sAH were younger and had significantly higher illness severity scores; they also faced a higher cumulative incidence of death at various time points (30, 90, and 180 days).
- After adjusting for other factors, results indicated that patients with sAH ACLF had a considerably higher risk of mortality compared to their non-sAH counterparts, underscoring the severity of sAH in critically ill patients.
Objectives: Mean arterial pressure is critically important in patients with cirrhosis in the ICU, however, there is limited data to guide therapies and targets.
Design: Retrospective observational study.
Setting: Tertiary care ICU.
Objective: To determine whether the mortality in a cohort of patients with psoriatic arthritis (PsA) from a single center in the UK is significantly different from the general UK population.
Methods: Patients who were entered onto the PsA database at the Royal National Hospital for Rheumatic Diseases, Bath, between 1985 and 2007 were included in this study. Information on patient deaths was collected retrospectively.
Rheumatoid arthritis (RA) is common and leads to joint damage due to persistent synovitis. The persistence of inflammation is maintained by hyperplastic stromal tissue, which drives the accumulation of leukocytes in the synovium. Aggressive treatment after the first 3-4 months of symptoms, with either disease modifying anti-rheumatic drugs or anti-tumor necrosis factor (TNF)-alpha therapy, reduces the rate of disease progression.
View Article and Find Full Text PDFAmino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch.
Am J Physiol Lung Cell Mol Physiol
June 2005
TNF-alpha-converting enzyme (TACE, ADAM17) cleaves membrane-associated cytokines and receptors and thereby regulates inflammatory and immune events, as well as lung development and mucin production. For example, the TACE-mediated cleavage of the type II 75-kDa TNF receptor (TNFR2) generates a soluble TNF-binding protein that modulates TNF bioactivity. TACE is synthesized as a latent proenzyme that is retained in an inactive state via an interaction between its prodomain and catalytic domain.
View Article and Find Full Text PDFSoluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa ectodomain of TNFR1 has been recognized as the mechanism by which soluble TNFR is shed. We now describe the release of exosome-like vesicles as a mechanism for the generation of soluble, full-length 55-kDa TNFR1.
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